New Approaches to Making the Microenvironment of the Female Reproductive Tract Hostile to HIV
Article first published online: 12 JAN 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Special Issue: Sexual Transmission of HIV in the 21st Century
Volume 65, Issue 3, pages 334–343, March 2011
How to Cite
Fahey, J. V., Bodwell, J. E., Hickey, D. K., Ghosh, M., Muia, M. N. and Wira, C. R. (2011), New Approaches to Making the Microenvironment of the Female Reproductive Tract Hostile to HIV. American Journal of Reproductive Immunology, 65: 334–343. doi: 10.1111/j.1600-0897.2010.00949.x
- Issue published online: 7 FEB 2011
- Article first published online: 12 JAN 2011
- Submitted November 12, 2010; accepted November 12, 2010.
- female reproductive tract;
- selective estrogen response modifier
Citation Fahey JV, Bodwell JE, Hickey DK, Ghosh M, Muia MN, Wira CR. New approaches to making the microenvironment of the female reproductive tract hostile to HIV. Am J Reprod Immunol 2011; 65: 334–343
The studies presented in this review explore three distinct areas with potential for inhibiting HIV infection in women. Based on emerging information from the physiology, endocrinology and immunology of the female reproductive tract (FRT), we propose unique ‘works in progress’ for protecting women from HIV. Various aspects of FRT immunity are suppressed by estradiol during the menstrual cycle, making women more susceptible to HIV infection. By engineering commensal Lactobacillus to secrete the anti-HIV molecule Elafin as estradiol levels increase, women could be protected from HIV infection. Selective estrogen response modifiers enhance barrier integrity and enhance secretion of protective anti-HIV molecules. Finally, understanding the interactions and regulation of FRT endogenous antimicrobials, proteases, antiproteases, etc., all of which are under hormonal control, will open new avenues to therapeutic manipulation of the FRT mucosal microenvironment. By seeking new alternatives to preventing HIV infection in women, we may finally disrupt the HIV pandemic.