Mast Cells and Ethanol Consumption: Interactions in the Prostate, Epididymis and Testis of UChB Rats
Article first published online: 18 JAN 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 66, Issue 3, pages 170–178, September 2011
How to Cite
Mendes, L. O., Amorim, J. P. A., Teixeira, G. R., Chuffa, L. G. A., Fioruci, B. A., Pimentel, T. A., de Mello Jr, W., Padovani, C. R., Pereira, S., Martinez, M., Pinheiro, P. F. F., Oliani, S. M. and Martinez, F. E. (2011), Mast Cells and Ethanol Consumption: Interactions in the Prostate, Epididymis and Testis of UChB Rats. American Journal of Reproductive Immunology, 66: 170–178. doi: 10.1111/j.1600-0897.2010.00958.x
- Issue published online: 5 AUG 2011
- Article first published online: 18 JAN 2011
- Submitted October 28, 2010; accepted November 28, 2010.
- mast cell;
Citation Mendes LO, Amorim JPA, Teixeira GR, Chuffa LGA, Fioruci BA, Pimentel TA, de Mello W Jr, Padovani CR, Pereira S, Martinez M, Pinheiro PFF, Oliani SM, Martinez FE. Mast cells and ethanol consumption: interactions in the prostate, epididymis and testis of UChB rats. Am J Reprod Immunol 2011; 66: 170–178
Problem Alcoholism has reached alarming proportions while fertility rates slowing in populations. The assessment of inflammatory effects with emphasis on the variation of the mast cells comparing ethanol chronic ingestion on reproductive organs deserves attention.
Method of study The mast cells were investigated with light microscopy using toluidine blue to locate and count total mast cells and immunohistochemistry to identify the connective tissue mast cells (CTMC).
Results The increase in total mast cells in the prostate, total and degranulated mast cells in epididymis of UChB rats was accompanied by a greater proportion of mucosal mast cells (MMC) in these organs. In addition, a lower incidence of degranulated mast cells was observed in epididymis of control rats.
Conclusions Ethanol increases the number of total and degranulated mast cells in the prostate and epididymis, as well as associated with increasing MMC, and therefore, it could be leading to inflammation in these organs.