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Mast Cells and Ethanol Consumption: Interactions in the Prostate, Epididymis and Testis of UChB Rats

Authors

  • Leonardo O. Mendes,

    1. Cellular and Structural Biology Program, Institute of Biology, Univ Estadual de Campinas – UNICAMP, Campinas, Brazil
    2. Department of Anatomy, Institute of Biosciences, UNESP – Univ Estadual Paulista, Botucatu – SP, Brazil
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  • João Paulo A. Amorim,

    1. Cellular and Structural Biology Program, Institute of Biology, Univ Estadual de Campinas – UNICAMP, Campinas, Brazil
    2. Department of Anatomy, Institute of Biosciences, UNESP – Univ Estadual Paulista, Botucatu – SP, Brazil
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  • Giovana R. Teixeira,

    1. Department of Anatomy, Institute of Biosciences, UNESP – Univ Estadual Paulista, Botucatu – SP, Brazil
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  • Luiz Gustavo A. Chuffa,

    1. Cellular and Structural Biology Program, Institute of Biology, Univ Estadual de Campinas – UNICAMP, Campinas, Brazil
    2. Department of Anatomy, Institute of Biosciences, UNESP – Univ Estadual Paulista, Botucatu – SP, Brazil
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  • Beatriz Aparecida Fioruci,

    1. Cellular and Structural Biology Program, Institute of Biology, Univ Estadual de Campinas – UNICAMP, Campinas, Brazil
    2. Department of Anatomy, Institute of Biosciences, UNESP – Univ Estadual Paulista, Botucatu – SP, Brazil
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  • Tatiana Aparecida Pimentel,

    1. Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, UNESP – Univ Estadual Paulista, São José do Rio Preto – SP, Brazil
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  • Wilson de Mello Jr,

    1. Department of Anatomy, Institute of Biosciences, UNESP – Univ Estadual Paulista, Botucatu – SP, Brazil
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  • Carlos Roberto Padovani,

    1. Department of Biostatistics, Institute of Biosciences, UNESP – Univ Estadual Paulista, Botucatu – SP, Brazil
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  • Sergio Pereira,

    1. Department of Anatomy, Institute of Biosciences, UNESP – Univ Estadual Paulista, Botucatu – SP, Brazil
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  • Marcelo Martinez,

    1. Department of Morphology and Pathology, Univ Federal de São Carlos, São Carlos – SP, Brazil
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  • Patrícia Fernanda F. Pinheiro,

    1. Department of Anatomy, Institute of Biosciences, UNESP – Univ Estadual Paulista, Botucatu – SP, Brazil
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  • Sônia Maria Oliani,

    1. Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, UNESP – Univ Estadual Paulista, São José do Rio Preto – SP, Brazil
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  • Francisco Eduardo Martinez

    1. Department of Anatomy, Institute of Biosciences, UNESP – Univ Estadual Paulista, Botucatu – SP, Brazil
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Francisco Eduardo Martinez, Department of Anatomy, Institute of Bioscience, UNESP – Univ Estadual Paulista, Caixa-Postal 510, CEP 18618-970, District of Rubião Jr., s/n, Botucatu, SP – Brazil.
E-mail: martinez@ibb.unesp.br

Abstract

Citation
Mendes LO, Amorim JPA, Teixeira GR, Chuffa LGA, Fioruci BA, Pimentel TA, de Mello W Jr, Padovani CR, Pereira S, Martinez M, Pinheiro PFF, Oliani SM, Martinez FE. Mast cells and ethanol consumption: interactions in the prostate, epididymis and testis of UChB rats. Am J Reprod Immunol 2011; 66: 170–178

Problem  Alcoholism has reached alarming proportions while fertility rates slowing in populations. The assessment of inflammatory effects with emphasis on the variation of the mast cells comparing ethanol chronic ingestion on reproductive organs deserves attention.

Method of study  The mast cells were investigated with light microscopy using toluidine blue to locate and count total mast cells and immunohistochemistry to identify the connective tissue mast cells (CTMC).

Results  The increase in total mast cells in the prostate, total and degranulated mast cells in epididymis of UChB rats was accompanied by a greater proportion of mucosal mast cells (MMC) in these organs. In addition, a lower incidence of degranulated mast cells was observed in epididymis of control rats.

Conclusions  Ethanol increases the number of total and degranulated mast cells in the prostate and epididymis, as well as associated with increasing MMC, and therefore, it could be leading to inflammation in these organs.

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