Serum Anti-Carbonic Anhydrase II Antibodies and Oxidant-Antioxidant Balance in Pre-eclampsia
Article first published online: 19 JAN 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 66, Issue 4, pages 297–303, October 2011
How to Cite
Aliyazicioglu, R., Guven, S., Mentese, A., Kolayli, S., Cengiz, S., Deger, O. and Alver, A. (2011), Serum Anti-Carbonic Anhydrase II Antibodies and Oxidant-Antioxidant Balance in Pre-eclampsia. American Journal of Reproductive Immunology, 66: 297–303. doi: 10.1111/j.1600-0897.2011.00981.x
- Issue published online: 9 SEP 2011
- Article first published online: 19 JAN 2011
- Submitted November 30, 2010; accepted December 19, 2010.
- carbonic anhydrase;
- lipid pre-oxidation;
Citation Aliyazicioglu R, Guven S, Mentese A, Kolayli S, Cengiz S, Deger O, Alver A. Serum anti-carbonic anhydrase II antibodies and oxidant-antioxidant balance in pre-eclampsia. Am J Reprod Immunol 2011; 66: 297–303
Problem The aim of this study was to investigate the presence of anti-carbonic anhydrase II antibodies (anti-CA II) antibodies in pre-eclampsia and the relationships between the autoantibodies, total antioxidant capacity (TAC) and total oxidant capacity (TOC), malondialdehyde (MDA) and oxidative stres index (OSI) parameters.
Method of study We studied 40 early and late onset pre-eclamptic patients and 40 healthy pregnant control and 39 healthy non-pregnant control subjects. Serum CA II antibodies, TAC and TOC, and MDA parameters were studied by ELISA.
Results The mean values for TAC, TOC, OSI, MDA, and anti-CA II were significantly increased in patients with pre-eclampsia compared to the other groups. The anti-CA II antibody levels for the pregnant control subjects were 0.129 ± 0.04 and that for the pre-eclamptic patients were 0.282 ± 0.18. In this study, any absorbance value higher than 0.136, the mean absorbance + 2 S.D. of pregnant control subjects, was defined as positive. Positive results were obtained in 29 of 40 pre-eclamptic patients (72.5%). There were significant positive correlations between serum anti-CA II antibodies and TOC, MDA levels, and OSI levels.
Conclusion The results suggest that anti-CA II antibodies and impairment in oxidant-antioxidant balance may be involved in multifactorial etiology of pre-eclampsia.