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References

  • 1
    Ascheim S, Zondek B: Hypophysenvorderlappen hormone und ovarialhormone im Harn von Schwangeren. Klin Wochenschr 1927; 6:1321.
  • 2
    Fishel SB, Edwards RG, Evans CJ: Human chorionic gonadotropin secreted by preimplantation embryos cultured in vitro. Science 1984; 223:816818.
  • 3
    Hearn JP, Gidley-Baird AA, Hodges JK, Summers PM, Webley GE: Embryonic signals during the pre-implantation period in primates. J Reprod Fertil Suppl 1988; 36:4958.
  • 4
    Talwar GP, Singh O, Pal R, Chatterjee N, Sahai P, Dhall K, Kaur J, Das SK, Suri S, Buckshee K: A vaccine that prevents pregnancy in women. Proc Natl Acad Sci USA 1994; 91:85328536.
  • 5
    Wolkersdörfer GW, Bornstein SR, Hilbers U, Zimmermann G, Biesold C, Lehmann M, Alexander H: The presence of chorionic gonadotrophin β subunit in normal cyclic human endometrium. Mol Hum Reprod 1998; 4:179184.
  • 6
    Dirnhofer S, Freund M, Rogatsch H, Krabichler S, Berger P: Selective expression of trophoblastic hormones by lung carcinoma: neuroendocrine tumors exclusively produce human chorionic gonadotropin α-subunit (hCGα). Hum Pathol 2000; 31:966972.
  • 7
    Dirnhofer S, Koessler P, Ensinger C, Feichtinger H, Madersbacher S, Berger P: Production of trophoblastic hormones by transitional cell carcinoma of the bladder: association to tumor stage and grade. Hum Pathol 1998; 29:377382.
  • 8
    Louhimo J, Carpelan-Holmstrom M, Alfthan H, Stenman UH, Jarvinen HJ, Haglund C: Serum hCG β, CA 72-4 and CEA are independent prognostic factors in colorectal cancer. Int J Cancer 2002; 101:545548.
  • 9
    Syrigos KN, Fyssas I, Konstandoulakis MM, Harrington KJ, Papadopoulos S, Milingos N, Peveretos P, Golematis BC: Beta human chorionic gonadotropin concentrations in serum of patients with pancreatic adenocarcinoma. Gut 1998; 42:8891.
  • 10
    Agnantis NJ, Patra F, Khaldi L, Filis S: Immunohistochemical expression of subunit beta HCG in breast cancer. Eur J Gynaecol Oncol 1992; 13:461466.
  • 11
    Crawford RA, Iles RK, Carter PG, Caldwell CJ, Shepherd JH, Chard T: The prognostic significance of human chorionic gonadotrophin and its metabolites in women with cervical carcinoma. J Clin Pathol 1998; 51:685688.
  • 12
    Hedstrom J, Grenman R, Ramsey H, Finne P, Lundin J, Haglund C, Alfthan H, Stenman UH: Concentration of free hCGβ subunit in serum as a prognostic marker for squamous-cell carcinoma of the oral cavity and oropharynx. Int J Cancer 1999; 84:525528.
  • 13
    de Bruijn HW, ten Hoor KA, Krans M, van der Zee AG: Rising serum values of β-subunit human chorionic gonadotrophin (hCG) in patients with progressive vulvar carcinomas. Br J Cancer 1997; 75:12171218.
  • 14
    Sheaff MT, Martin JE, Badenoch DF, Baithun SI: hCG as a prognostic marker in adenocarcinoma of the prostate. J Clin Pathol 1996; 49:329332.
  • 15
    Zhang W, Yang H, Han S: The effect of ectopic HCG on microvessel density in gastric carcinoma. Chin J Oncol 1998; 20:351353.
  • 16
    Perrier d’Hauterive S, Charlet-Renard C, Berndt S, Dubois M, Munaut C, Goffin F, Hagelstein MT, Noe¨l A, Hazout A, Foidart JM, Geenen V: Human chorionic gonadotropin and growth factors at the embryonic-endometrial interface control leukemia inhibitory factor (LIF) and interleukin 6 (IL-6) secretion by human endometrial epithelium. Hum Reprod 2004; 19:26332643.
  • 17
    Schafer A, Pauli G, Friedmann W, Dudenhausen JW: Human chorionic gonadotropin (HCG) and placental lactogen (hPL) inhibit interleukin-2 (IL-2) and increase interleukin-1β (IL-1β), -6 (IL-6) and tumor necrosis factor (TNF-α) expression in monocyte cell cultures. J Perinat Med 1992; 20:233240.
  • 18
    Han T: Inhibitory effect of human chorionic gonadotrophin on lymphocyte blastogenic response to mitogen, antigen and allogeneic cells. Clin Exp Immunol 1974; 18:529535.
  • 19
    Hammarström L, Fuchs T, Smith CI: The immunodepressive effect of human glucoproteins and their possible role in the non-rejection process during pregnancy. Acta Obstet Gynecol Scand 1979; 58:417422.
  • 20
    Kaye MD, Jones WR: Effect of human chorionic gonadotropin on in vitro lymphocyte transformation. Am J Obstet Gynecol 1971; 109:10291031.
  • 21
    Adcock EW, Teasdale T, August CS, Cox S, Meschia G, Ballaglia TC, Naughton MA: Human chorionic gonadotropin: its possible role in maternal lymphocyte suppression. Science 1973; 181:845847.
  • 22
    Wan H, Versnel MA, Cheung WY, Leenen PJ, Khan NA, Benner R, Kiekens RC: Chorionic gonadotropin can enhance innate immunity by stimulating macrophage function. J Leukoc Biol 2007; 82:926933.
  • 23
    Schumacher A, Brachwitz N, Sohr S, Engeland K, Langwisch S, Dolaptchieva M, Alexander T, Taran A, Malfertheiner SF, Costa SD, Zimmermann G, Nitschke C, Volk HD, Alexander H, Gunzer M, Zenclussen AC: Human chorionic gonadotropin attracts regulatory T Cells into the fetal–maternal interface during early human pregnancy. J Immunol 2009; 182:54885497.
  • 24
    Tang B, Gurpide E: Direct effect of gonadotropins on decidualization of human endometrial stroma cells. J Steroid Biochem Mol Biol 1993; 47:115121.
  • 25
    Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JF: Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 1986; 118:15671582.
  • 26
    Dhar R, Karmakar S, Sriraman R, Talwar GP, Das C: Efficacy of a recombinant chimeric Anti-hCG antibody to prevent human cytotrophoblasts fusion and block progesteron synthesis. Am J Reprod Immunol 2004; 51:358363.
  • 27
    Wulff C, Dickson SE, Duncan WC, Fraser HM: Angiogenesis in the human corpus luteum: simulated early pregnancy by hCG treatment is associated with both angiogenesis and vessel stabilization. Hum Reprod 2001; 16:25152524.
  • 28
    Gillott DJ, lles RK, Chard T: The effects of β-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines. Br J Cancer 1996; 73:323326.
  • 29
    Butler SA, Ikram MS, Mathieu S, Iles RK: The increase in bladder carcinoma cell population induced by the free beta subunit of human chorionic gonadotrophin is a result of an anti-apoptosis effect and not cell proliferation. Br J Cancer 2000; 82:15531556.
  • 30
    Kayisli UA, Selam B, Guzeloglu-Kayisli O, Demir R, Arici A: Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system. J Immunol 2003; 171:23052313.
  • 31
    Jankowska A, Gunderson SI, Andrusiewicz M, Burczynska B, Szczerba A, Jarmolowski A, Nowak-Markwitz E, Warchol JB: Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells. Mol Cancer 2008; 7:26.
  • 32
    Wu W, Walker AM: Human chorionic gonadotropin β (HCGβ) down-regulates E-cadherin and promotes human prostate carcinoma cell migration and invasion. Cancer 2006; 106:6878.
  • 33
    Frixen UH, Behrens J, Sachs M: E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991; 113:173185.
  • 34
    Bellet D, Lazar V, Bièche I, Paradis V, Giovangrandi Y, Paterlini P, Lidereau R, Bedossa P, Bidart JM, Vidaud M: Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin β Genes normally transcribed in trophoblastic cell. Cancer Res 1997; 57:516523.
  • 35
    Palaniappan M, Menon KM: Human chorionic gonadotropin stimulates theca-interstitial cell proliferation and cell cycle regulatory proteins by a cAMP-dependent activation of AKT/mTORC1 signaling pathway. Mol Endocrinol 2010; 24:17821793.
  • 36
    Csapo Al, Pulkkinen MO, Rutter B, Sauvage JP, Wiest WG: The significance of the human corpus luteum in pregnancy maintenance. Am J Obstet Gynecol 1972; 112:10611067.
  • 37
    Tandon A, Das C, Jaikhani BL, Talwar GP: Efficacy of antibodies generated by PR-β-hCG-TT to terminate pregnancy in baboons: its reversibility and rescue by medroxyprogesterone acetate. Contraception 1981; 24:8395.
  • 38
    Köhler G, Milstein C: Continuous cultures of fused cells secreting antibody of pre defined specificity. Nature 1975; 256:495497.
  • 39
    Gupta SK, Talwar GP: Development of hybridomas secreting anti-human chorionic gonadotropin antibodies. Indian J Exp Biol 1980; 18:13611365.
  • 40
    Kathuria S, Sriraman R, Nath R, Sack M, Pal R, Artsaenko O, Talwar GP, Fischer R, Finnern R: Efficacy of plant-produced recombinant antibodies against HCG. Hum Reprod 2002; 17:20542061.
  • 41
    Kathuria S, Nath R, Pal R, Singh O, Fischer R, Lohiya NK, Talwar GP: Functional recombinant antibodies against human chorionic gonadotropin expressed in plants. Curr Sci 2002; 82:14521457.
  • 42
    Sriraman R, Bardor M, Vaquero C, Faye L, Fischer R, Finner R, Lerouge P: Recombinant anti-hCG antibodies retained in the endoplasmic reticulum of transformed plants lack core-xylose and core- α(1,3)-fucose residues. Plant Biotech J 2004; 2:279280.
  • 43
    Dawood MY, Saxena BB, Landesman R: Human chorionic gonadotropin and its subunits in hydatidiform mole and choriocarcinoma. Obstet Gynecol 1977; 50:172181.
  • 44
    Jones-Brown YR, Wu CY, Weintraub BD, Rosen SW: Synthesis of chorionic gonadotropin subunits in human choriocarcinoma clonal cell line JEG-3: carbohydrate differences in glycopeptides from free and combined alpha-subunits. Endocrinology 1984; 115:14391445.
  • 45
    Talwar GP, Purswani S, Vyas HK: Immunological approaches against human chorionic gonadotropin for control of fertility and advanced stage cancers expressing ectopically hCG. In Gonadal and Nongonadal Actions of Gonadotropins, AKumar, CVRao, PKChaturvedi (eds). New Delhi, Narosa Publishing House, 2010, pp 183196.
  • 46
    Kabeer RS, Pal R, Talwar GP: Human acute lymphoblastic leukemia cells make human pregnancy hormone hCG and expose it on the membrane: a case for using recombinant antibody against hCG for selective delivery of drugs and/or radiations. Curr Sci 2005; 89:15711576.
  • 47
    Talwar GP, Gupta R, Gupta SK, Malhotra R, Khanna R, Mitra DK, Sehgal S, Minz R, Kumar A: A monoclonal antibody cytolytic to androgen independent DU145 and PC3 human prostatic carcinoma cells. Prostate 2001; 46:207213.
  • 48
    Jurianz K, Ziegler S, Garcia-Schüler H, Kraus S, Bohana-Kashtan O, Fishelson Z, Kirschfink M: Complement resistance of tumor cells: basal and induced mechanisms. Mol Immunol 1999; 36:929939.
  • 49
    Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY: Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or premalignant lesions. Anticancer Res 2001; 21:28952900.
  • 50
    Aggarwal BB, Shishodia S: Suppression of the nuclear factor-kappa B activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann NY Acad Sci 2004; 1030:434441.
  • 51
    Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB: Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of I kappa B alpha kinase and Akt activation. Mol Pharmacol 2006; 69:195206.
  • 52
    Vyas HK, Pal R, Vishwakarma R, Lohiya NK, Talwar GP: Selective killing of leukemia and lymphoma cells ectopically expressing hCGβ by a conjugate of curcumin with an antibody against hCGβ subunit. Oncology 2009; 76:101111.
  • 53
    Kumar S, Talwar GP, Biswas DK: Necrosis and inhibition of growth of human lung tumor by anti-alpha-human chorionic gonadotropin antibody. J Natl Cancer Inst 1992; 84:4247.
  • 54
    Talwar GP, Singh O, Rao LV: An improved immunogen for anti hCG vaccine eliciting antibodies reactive with a conformation native to the hormone without cross reaction with human follicle stimulating hormone. J Reprod Immunol 1988; 14:203212.
  • 55
    Talwar GP, Singh O: Birth control vaccine inducing antibodies against chorionic gonadotropin. In Contraception Research for Today and the Nineties, GPTalwar (ed). New York, Springer Verlag, 1988, pp 183199.
  • 56
    Herzenberg LA, Hayakawa K, Hardy RR, Tokuhisa T, Oi VT, Herzenberg LA: Molecular, cellular and systemic mechanisms for regulating IgCH expression. Immunol Rev 1982; 67:531.
  • 57
    Gaur A, Arunan K, Singh O, Talwar GP: Bypass by an alternate carrier of acquired unresponsiveness to hCG upon repeated immunization with tetanus conjugated vaccine. Int Immunol 1990; 2:151155.
  • 58
    Pal R, Singh O, Rao LV, Talwar GP: Bioneutralization capacity of the antibodies generated in women by the beta subunit of human chorionic gonadotropin (beta hCG) and beta hCG associated with the alpha subunit of ovine luteinizing hormone linked to carriers. Am J Reprod Immunol 1990; 22:124126.
  • 59
    Kharat I, Niar NS, Dhall K, Sawhney H, Krishna O, Shahani SM, Banerjee AK, Roy S, Hingorani V, Singh O, Talwar GP: Analysis of menstrual records of women immunized with anti-hCG vaccine inducing antibodies partially cross-reactive with hLH. Contraception 1990; 41:293299.
  • 60
    Talwar GP, Hingorani V, Kumar S, Roy S, Banerjee A, Shahani SM, Krishna U, Dhall K, Sawhney H, Sharma NC: Phase I clinical trials with three formulations of anti-hCG vaccine. Contraception 1990; 41:301316.
  • 61
    Singh M, Das SK, Suri S, Singh O, Talwar GP: Regain of fertility and normality of progeny born at below protective threshold antibody titers in women immunized with the HSD-hCG vaccine. Am J Reprod Immunol 1998; 39:395398.
  • 62
    Talwar GP, Singh O, Gupta SK, Hasnain SE, Pal R, Majumdar SS, Vrati S, Mukhopadhyay A, Srinivasan J, Deshmukh U, Ganga S, Mandokhot A, Gupta A: The HSD-hCG vaccine prevents pregnancy in women, fesability studies of reversibily safe contraception vaccine. Am J Reprod Immunol 1997; 37:153160.
  • 63
    Talwar GP, Mustafa AS, et al.: 14 Papers in Golden Jubilee Issue Leprosy in India 1978; 50, 492597.
  • 64
    Talwar GP: An immunotherapeutic vaccine for multibacillary leprosy. Int Rev Immunol 1999; 18:229249.
  • 65
    Patel N, Trapathi SB: Improved cure rates in pulmonary tuberculosis category II (retreatment) with Mycobacterium w. J Indian Med Assoc 2003; 101:680682.
  • 66
    Ahmed N, Saini V, Raghuvanshi S, Khurana JP, Tyagi AK, Tyagi AK, Hasnain SE: Molecular analysis of a Leprosy immunotherapeutic bacillus provides insights into Mycobacterium evolution. PLoS ONE 2007; 2:e968.
  • 67
    Saini V, Raghuvanshi S, Talwar GP, Ahmed N, Khurana JP, Hasnain SE, Tyagi AK: Polyphasic taxonomic analysis establishes Mycobacterium indicus pranii as a distinct species. PLoS ONE 2009; 4:e6263.
  • 68
    Talwar GP, Ahmad N, Saini V: The use of the name Mycobacterium W for the leprosy immunotherapeutic bacillus creates confusion with M. tuberculosis-W (Beijing strain): a suggestion. Infect Genet Evol 2008; 8:100101.
  • 69
    Ramakrishnan S, Das C, Dubey SK, Salahuddin M, Talwar GP: Immunogenicity of three C-terminal synthetic peptides of the beta subunit of human chorionic gonadotropin and properties of the antibodies raised against 45-amino acid C-terminal peptide. J Reprod Immunol 1979; 1:249261.
  • 70
    Stevens VC, Cinaver B, Powell JE, Lee SE, Koh SW: Preparation and formulation of a hCG antifertility vaccine. Selection of adjuvant and vehicle. Am J Reprod Immunol Microbiol 1981; 6:315321.
  • 71
    Jones WR, Bradley J, Judd SJ, Denholm EH, Ing RM, Mueller UW, Powell J, Griffin PD, Stevens VC: Phase I clinical trial of a World Health Organization birth control vaccine. Lancet 1988; 1:12951298.
  • 72
    Purswani S, Talwar GP: Development of a highly immunogenic recombinant candidate vaccine against human chorionic gonadotropin. Vaccine 2011; 29:23412348.
  • 73
    Salmond RJ, Luross JA, Williams NA: Immune modulation by the cholera-like enterotoxins. Expert Rev Mol Med 2002; 4:116.
  • 74
    Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW: Crystal structure of human chorionic gonadotropin. Nature 1994; 369:455461.
  • 75
    Rappuoli R, Pizza M, Douce G, Dougan G: Structure and mucosal adjuvanticity of cholera and Escherichia coli heat labile enterotoxins. Immunol Today 1999; 20:493500.
  • 76
    Ricci S, Medaglini D, Rush CM, Marcello A, Peppoloni S, Manganelli R, Palu G, Pozzi G: Immunogenicity of the B Monomer of Escherichia coli Heat-Labile Toxin Expressed on the Surface of Streptococcus gordonii. Infect Immun 2000; 68:760766.
  • 77
    Talwar GP, Sharma NC, Dubey SK, Salahuddin M, Das C, Ramakrishnan S, Kumar S, Hingorani V: Isoimmunisation against human chorionic gonadotropin with conjugates of processed beta subunit of the hormone and tetanus toxoid. Proc Natl Acad Sci USA 1976; 73:218222.
  • 78
    Gupta A, Pal R, Ahlawat S, Bhatia P, Singh O: Enhanced immunogenicity of a contraceptive vaccine using diverse synthetic carriers. Vaccine 2001; 19:33843389.
  • 79
    Charrel-Dennis M, Terrazzini N, McBride JD, Kaye P, Martensen PM, Justesen J, Berger P, Lapthorn A, Kelly C, Roitt IM, Delves PJ, Lund T: The human chorionic gonadotropin-beta arginine68 to glutamic acid substitution fixes the conformation of the C-terminal peptide. Mol Endocrinol 2005; 19:18031811.
  • 80
    He LZ, Ramakrishna V, Connolly JE, Wang XT, Smith PA, Jones CL, Valkova-Valchanova M, Arunakumari A, Treml JF, Goldstein J, Wallace PK, Keler T, Endres MJ: A novel human cancer vaccine elicits cellular responses to the tumor-associated antigen, human chorionic gonadotropin β. Clin Cancer Res 2004; 10:19201927.