Transforming Growth Factor-β1 Gene Polymorphisms in Korean Women With Endometriosis
Article first published online: 27 MAY 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 66, Issue 5, pages 428–434, November 2011
How to Cite
Lee, H. J., Kim, H., Ku, S.-Y., Kim, S. H. and Kim, J. G. (2011), Transforming Growth Factor-β1 Gene Polymorphisms in Korean Women With Endometriosis. American Journal of Reproductive Immunology, 66: 428–434. doi: 10.1111/j.1600-0897.2011.01009.x
- Issue published online: 11 OCT 2011
- Article first published online: 27 MAY 2011
- Submitted December 3, 2010; accepted March 3, 2011.
- gene polymorphism;
- transforming growth factor β1
Citation Lee HJ, Kim H, Ku S-Y, Kim SH, Kim JG. Transforming growth factor-β1 gene polymorphisms in Korean women with endometriosis. Am J Reprod Immunol 2011; 66: 428–434
Problem To investigate the association between endometriosis, transforming growth factor-β1 (TGFB1) gene polymorphisms, and serum TGF-β1 levels in Korean women.
Method of study The −509C/T, 868T/C, 913G/C and 979G/A polymorphisms of the TGFB1 gene were analyzed in women with (n = 131) and without (n = 107) endometriosis using restriction fragment length polymorphism (RFLP) analysis. Serum TGF-β1 levels were measured by enzyme-linked immunosorbent assay (ELISA).
Results The 913G/C and 979G/A polymorphisms were not observed in the study participants. The genotype and allele distribution of the −509C/T and 868T/C polymorphisms in endometriosis were similar to those in controls. However, the −509T/868C (TC) haplotype allele was observed 4.55 times more frequently in early-stage endometriosis than in other haplotype alleles. Serum TGF-β1 levels were significantly higher in endometriosis than in controls. The single and haplotype genotype of −509C/T and 868T/C polymorphisms were not related with serum TGF-β1 levels.
Conclusion The TC haplotype allele of TGFB1−509C/T and 868T/C polymorphisms may be associated with early-stage endometriosis in Korean women.