Elevated Serum Levels of Interleukin-6, Interleukin-1β and Human Chorionic Gonadotropin in Pre-eclampsia
Article first published online: 30 MAY 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 66, Issue 6, pages 468–475, December 2011
How to Cite
Kalinderis, M., Papanikolaou, A., Kalinderi, K., Ioannidou, E., Giannoulis, C., Karagiannis, V. and Tarlatzis, B. C. (2011), Elevated Serum Levels of Interleukin-6, Interleukin-1β and Human Chorionic Gonadotropin in Pre-eclampsia. American Journal of Reproductive Immunology, 66: 468–475. doi: 10.1111/j.1600-0897.2011.01019.x
- Issue published online: 10 NOV 2011
- Article first published online: 30 MAY 2011
- Submitted January 26, 2011; accepted April 5, 2011.
- Human chorionic gonadotropin;
Citation Kalinderis M, Papanikolaou A, Kalinderi K, Ioannidou E, Giannoulis C, Karagiannis V, Tarlatzis BC. Elevated serum levels of interleukin-6, interleukin-1β and human chorionic gonadotropin in pre-eclampsia. Am J Reprod Immunol 2011; 66: 468–475
Problem Pre-eclampsia (PE) is a pregnancy-specific syndrome of unknown aetiology. It is believed to involve an inflammatory process. The aim of the study was to investigate and compare the concentrations of two proinflammatory cytokines interleukin-6 (IL-6) and interleukin-1β (IL-1β) and to evaluate the possible interaction between them and human chorionic gonadotropin (hCG) in women with normotensive pregnancy and PE.
Method of study A prospective case–control study was carried out in 30 women with PE and 30 normotensive controls. Serum IL-1β, IL-6 and hCG levels were determined by enzyme-linked immunosorbent assay (ELISA) and automated immunofluorescent assay, respectively.
Results Serum IL-6, IL-1β and hCG levels were significantly increased in women with PE compared to controls (P < 0.001 for each); however, no correlation was found between IL-6, IL-1β and hCG.
Conclusion Our results highlight the inflammatory origin of PE and reinforce the possible role of hCG in the complex aetiology of its pathogenesis.