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Celiac Disease and Gyneco-obstetrics Complications: Can Serum Antibodies Modulate Tissue Transglutaminase Functions and Contribute to Clinical Pattern?


Ana Hernández, Cátedra de Inmunología, Instituto de Higiene, Alfredo Navarro 3051, Montevideo, Uruguay.


Citation Sóñora C, Muñoz F, Del Río N, Acosta G, Montenegro C, Trucco E, Hernández A. Celiac disease and gyneco-obstetrics complications: can serum antibodies modulate tissue transglutaminase functions and contribute to clinical pattern? Am J Reprod Immunol 2011; 66: 476–487

Problem  Untreated celiac disease (CD) is often associated with early miscarriages, infertility, and alterations in menstrual cycle. Tissue transglutaminase (tTG) antibodies could be involved by interfering with tTG transamidating activity and/or biological functions mediated by its interaction with fibronectin (FN).

Method of study  The correlation between the presence of extra-digestive disorders and the reactivity of sera against tTG-FN and its effects on tTG transamidating activity was analyzed in a group or 50 women with recently diagnosed CD.

Results  Heterogeneous behavior was observed among serum samples derived from patients with different complaints, suggesting that differences in fine specificity patterns could condition clinical outcome. Sera from women with gynecological and/or obstetric problems induced significant inhibition of in vitro enzymatic activity in comparison with those without these kinds of disorders.

Conclusions  The significant correlation observed between serum effects and clinical profile suggests a putative involvement of tTG-specific antibodies in gynecological and/or obstetric disorders during active CD.