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Keywords:

  • Antiphospholipid antibodies;
  • anti-prothrombin antibodies;
  • fetal death;
  • placental abruption;
  • pre-eclampsia;
  • pregnancy outcome

Citation Marozio L, Curti A, Botta G, Canuto EM, Salton L, Tavella AM, Benedetto C. Anti-prothrombin antibodies are associated with adverse pregnancy outcome. Am J Reprod Immunol 2011; 66: 404–409

Problem  Women with antiphospholipid antibodies (aPL) such as lupus anticoagulant, anticardiolipin antibodies, and anti-β2 glycoprotein-1 antibodies are at high risk of late pregnancy complications, such as severe pre-eclampsia, placental insufficiency, and fetal loss. It has been observed that aPL consists of a heterogeneous group of antibodies targeting several phospholipid-binding plasma proteins, including also anti-prothrombin (anti-PT), anti-protein S (anti-PS), and anti-protein C (anti-PC) antibodies. Their potential role in late pregnancy complications is not known. The aim of this work was to investigate the association between those autoantibodies and histories for adverse pregnancy outcome.

Method of study  Anti-PT, anti-PS, and anti-PC antibodies were evaluated in 163 patients with previous severe pre-eclampsia, fetal death, and/or placental abruption and in as many women with previous uneventful pregnancies, negative for aPL.

Results  The prevalence of anti-PT antibodies was higher in cases than in controls (OR, 95% CI: 10.92, 4.52–26.38). The highest prevalence was observed in subjects with fetal death.

Conclusion  Anti-PT antibodies appear to be associated with adverse pregnancy outcome, irrespectively of aPL.