Uterine Regulatory T cells, IL-10 and Hypertension


Surendra Sharma, Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI, USA.
E-mail: ssharma@wihri.org


Citation Nevers T, Kalkunte S, Sharma S. Uterine Regulatory T Cells, IL-10 and hypertension. Am J Reprod Immunol 2011; 66 (Suppl. 1): 88–92


Regulatory T cells (Treg) are a vital immune cellular population at the maternal–fetal interface. They are likely to aid in immune tolerance by dampening the harmful effects of other immune cellular populations through cell–cell-mediated interactions as well as by producing IL-10 and TGF-β. In addition to the anti-inflammatory properties, IL-10 has emerged as an important vascular cytokine choreographing endovascular interactions and angiogenesis and regulates hypertension.

Method of study

Review of innovative concepts to understand the temporal role of Tregs in both mouse and human pregnancy, particularly whether uterine Treg play a potential role in regulating vascular homeostasis and blood flow during pregnancy.


Treg guard immune tolerance, getting cytotoxically activated under certain conditions, leading to adverse pregnancy outcome.


Despite increasing evidence of Treg tissue-specific expansion and functional plasticity, their role in vascular activity, pre-eclampsia or gestational diabetes is obscure and needs closer investigation to delineate its role later during pregnancy.