Uterine Regulatory T cells, IL-10 and Hypertension
Article first published online: 4 JUL 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Special Issue: Marcus Wallenberg International Symposium in Comparative Reproductive Immunology, “Immunology at the fetal maternal interface: Basic science and clinical applications”, July 7–8th, 2011, Linköping University, Sweden
Volume 66, Issue Supplement s1, pages 88–92, July 2011
How to Cite
Nevers, T., Kalkunte, S. and Sharma, S. (2011), Uterine Regulatory T cells, IL-10 and Hypertension. American Journal of Reproductive Immunology, 66: 88–92. doi: 10.1111/j.1600-0897.2011.01040.x
- Issue published online: 4 JUL 2011
- Article first published online: 4 JUL 2011
- Submitted May 5, 2011; accepted May 18, 2011.
- regulatory T cells;
- vascular activity
Citation Nevers T, Kalkunte S, Sharma S. Uterine Regulatory T Cells, IL-10 and hypertension. Am J Reprod Immunol 2011; 66 (Suppl. 1): 88–92
Regulatory T cells (Treg) are a vital immune cellular population at the maternal–fetal interface. They are likely to aid in immune tolerance by dampening the harmful effects of other immune cellular populations through cell–cell-mediated interactions as well as by producing IL-10 and TGF-β. In addition to the anti-inflammatory properties, IL-10 has emerged as an important vascular cytokine choreographing endovascular interactions and angiogenesis and regulates hypertension.
Method of study
Review of innovative concepts to understand the temporal role of Tregs in both mouse and human pregnancy, particularly whether uterine Treg play a potential role in regulating vascular homeostasis and blood flow during pregnancy.
Treg guard immune tolerance, getting cytotoxically activated under certain conditions, leading to adverse pregnancy outcome.
Despite increasing evidence of Treg tissue-specific expansion and functional plasticity, their role in vascular activity, pre-eclampsia or gestational diabetes is obscure and needs closer investigation to delineate its role later during pregnancy.