Present address: Tytgat institute for Liver and Intestinal Research of the Academic Medical Center, University of Amsterdam, the Netherlands.
Regulatory T Helper Cells in Pregnancy and their Roles in Systemic versus Local Immune Tolerance
Article first published online: 4 JUL 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Special Issue: Marcus Wallenberg International Symposium in Comparative Reproductive Immunology, “Immunology at the fetal maternal interface: Basic science and clinical applications”, July 7–8th, 2011, Linköping University, Sweden
Volume 66, Issue Supplement s1, pages 31–43, July 2011
How to Cite
Ernerudh, J., Berg, G. and Mjösberg, J. (2011), Regulatory T Helper Cells in Pregnancy and their Roles in Systemic versus Local Immune Tolerance. American Journal of Reproductive Immunology, 66: 31–43. doi: 10.1111/j.1600-0897.2011.01049.x
- Issue published online: 4 JUL 2011
- Article first published online: 4 JUL 2011
- Submitted April 26, 2011; accepted May 5, 2011.
- reproductive immunology;
- T helper cell;
Citation Ernerudh J, Berg G, Mjösberg J. Regulatory T Helper Cells in Pregnancy and their Roles in Systemic versus Local Immune Tolerance. Am J Reprod Immunol 2011; 66 (Suppl. 1): 31–43
Problem During pregnancy, the maternal immune system needs to adapt in order not to reject the semi-allogenic fetus.
Method In this review, we describe and discuss the role of regulatory T (Treg) cells in fetal tolerance.
Results Treg cells constitute a T helper lineage that is derived from thymus (natural Treg cells) or is induced in the periphery (induced Treg cells). Treg cells are enriched at the fetal-maternal interface, showing a suppressive phenotype. In contrast, Treg cells are not increased in the circulation of pregnant women, and the suppressive capacity is similar to that in non-pregnant women. However, aberrations in Treg frequencies and functions, both systemically and in the uterus, may be involved in the complications of pregnancy.
Conclusion Treg cells seem to have distinguished roles locally versus systemically, based on their distribution and phenotype.