Epigenetics – the Key to Understand Immune Responses in Health and Disease
Article first published online: 4 JUL 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Special Issue: Marcus Wallenberg International Symposium in Comparative Reproductive Immunology, “Immunology at the fetal maternal interface: Basic science and clinical applications”, July 7–8th, 2011, Linköping University, Sweden
Volume 66, Issue Supplement s1, pages 72–74, July 2011
How to Cite
Janson, P. C. and Winqvist, O. (2011), Epigenetics – the Key to Understand Immune Responses in Health and Disease. American Journal of Reproductive Immunology, 66: 72–74. doi: 10.1111/j.1600-0897.2011.01050.x
- Issue published online: 4 JUL 2011
- Article first published online: 4 JUL 2011
- Submitted May 17, 2011, Accepted May 25, 2011.
Citation Janson PC, Winqvist O. Epigenetics – the Key to Understand Immune Responses in Health and Disease. Am J Reprod Immunol 2011; 66 (Suppl. 1): 72–74
Problem Development of alternative CD4+ T cells provides flexibility to the immune system. This is crucial for the initiation of appropriate effector mechanisms to protect against various pathogens such as bacteria, viruses, tumors, and parasites.
Method of study Review of research on the epigenetic regulation of T-cell subsets.
Results Studies of the epigenetic modulation of T-cell subset function/dysfunction during the past years have increased our understanding of how the alternative effector populations arise and how their identity is maintained during clonal expansion.
Conclusions The recent advances in epigenetic research within the field of immunology have also raised questions on how immunology is regulated during pregnancy and early life and how epigenetic regulation of the immune system during prenatal development is related to diseases later in life such as autoimmunity and allergy.