Immunohistochemistrical and Clinicopathological Characterization of Chronic Endometritis
Article first published online: 12 JUL 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 66, Issue 5, pages 410–415, November 2011
How to Cite
Kitaya, K. and Yasuo, T. (2011), Immunohistochemistrical and Clinicopathological Characterization of Chronic Endometritis. American Journal of Reproductive Immunology, 66: 410–415. doi: 10.1111/j.1600-0897.2011.01051.x
- Issue published online: 11 OCT 2011
- Article first published online: 12 JUL 2011
- Submitted February 21, 2011; accepted May 27, 2011.
- Chronic endometritis;
- endometrial dating;
- endometrial stromal plasmacytes;
- menstrual disturbances
Citation Kitaya K, Yasuo T. Immunohistochemistrical and clinicopathological characterization of chronic endometritis. Am J Reprod Immunol 2011; 66: 410–415
Problem Chronic endometritis is an elusive entity that is often asymptomatic and undetectable by conventional endometrial biopsy and histological examination. Using immunohistochemistry for full-thickness endometrium, we sought for its clinicopathological features.
Method of Study Two hundred and thirty-four archival endometrial specimens obtained by hysterectomy were immunostained for the plasmacyte marker syndecan-1 to identify chronic endometritis. Endometrial morphology was dated by the standard criteria. The immunoreactive cells were enumerated in 10 non-overlapping endometrial stromal areas. The clinical parameters were obtained from the medical charts.
Results Chronic endometritis was identified in 11.1% of the samples examined. Its occurrence was similar between the proliferative phase and secretory phase. A total of 23.1% of the cases were asymptomatic. Stromal plasmacyte infiltration and morphological delay were more prominent in symptomatic chronic endometritis than in asymptomatic counterpart.
Conclusions Chronic endometritis is a common gynecological pathological condition and more often asymptomatic than ever expected. There was no menstrual cycle-dependent fluctuation in its occurrence.