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Polymorphisms of Dioxin Receptor Complex Components and Detoxification-Related Genes Jointly Confer Susceptibility to Advanced-Stage Endometriosis in the Taiwanese Han Population

Authors


Chao-Chin Hsu, Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, 291 Jhongjheng Rd., Jhonghe District, New Taipei City 23561, Taiwan.
E-mail: tube2363808@gmail.com
Pao-Lin Kuo, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan 704, Taiwan.
E-mail: paolink@mail.ncku.edu.tw

Abstract

Citation Wu C-H, Guo C-Y, Yang J-G, Tsai H-D, Chang Y-J, Tsai P-C, Hsu C-C, Kuo P-L. Polymorphisms of dioxin receptor complex components and detoxification-related genes jointly confer susceptibility to advanced-stage endometriosis in the Taiwanese Han population. Am J Reprod Immunol 2012; 67: 160–168

Problem  To establish a multilocus model for studying the effect of dioxin receptor complex components and detoxification-related enzymes on advanced endometriosis.

Method of study  Six single-nucleotide polymorphisms (SNPs) and two deletion polymorphisms from eight genes (CYP1A1, CYP1B1, GSTM1, GSTT1, GSTP1, AhR, ARNT, and AhRR) were genotyped.

Results  In the single SNP analysis, GSTM1 null type and AhRR variant type were associated with a significantly increased risk of endometriosis [odds ratio (OR) = 2.38 and 2.45, respectively]. Using multiple SNPs in the logistic regression for covariates, wild-type AhR and mutant AhRR combination was significantly higher in patients (67.8%) than in controls (48.0%) (OR = 2.76). On the other hand, mutant AhRR in combination with GSTM1 null genotype was significantly higher in patients (35.5%) than in controls (19.3%) (OR = 6.12).

Conclusion  Polymorphisms of dioxin receptor complex components and detoxification-related genes jointly confer susceptibility to advanced-stage endometriosis in the Taiwanese Han population.

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