Postpartum Group A Streptococcus Sepsis and Maternal Immunology
Article first published online: 24 OCT 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 67, Issue 2, pages 91–100, February 2012
How to Cite
Mason, K. L. and Aronoff, D. M. (2012), Postpartum Group A Streptococcus Sepsis and Maternal Immunology. American Journal of Reproductive Immunology, 67: 91–100. doi: 10.1111/j.1600-0897.2011.01083.x
- Issue published online: 4 JAN 2012
- Article first published online: 24 OCT 2011
- Submitted September 2, 2011; accepted September 26, 2011.
- Female reproductive tract;
- Group A Streptococcus;
- maternal immunology;
- postpartum sepsis
Citation Mason KL, Aronoff DM. Postpartum group A Streptococcus sepsis and maternal immunology. Am J Reprod Immunol 2012; 67: 91–100
Group A Streptococcus (GAS) is an historically important agent of puerperal infections and sepsis. The inception of hand-washing and improved hospital hygiene drastically reduced the incidence of puerperal sepsis, but recently the incidence and severity of postpartum GAS infections has been rising for uncertain reasons. Several epidemiological, host, and microbial factors contribute to the risk for GAS infection and mortality in postpartum women. These include the mode of delivery (vaginal versus cesarean section), the location where labor and delivery occurred, exposure to GAS carriers, the altered immune status associated with pregnancy, the genetic background of the host, the virulence of the infecting GAS strain, and highly specialized immune responses associated with female reproductive tract tissues and organs. This review will discuss the complicated factors that contribute to the increased susceptibility to GAS after delivery and potential reasons for the recent increase observed in morbidity and mortality.