Two-Way Calf to Dam Major Histocompatibility Class I Compatibility Increases Risk for Retained Placenta in Cattle
Article first published online: 30 OCT 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 67, Issue 3, pages 224–230, March 2012
How to Cite
Benedictus, L., Thomas, A. J., Jorritsma, R., Davies, C. J. and Koets, A. P. (2012), Two-Way Calf to Dam Major Histocompatibility Class I Compatibility Increases Risk for Retained Placenta in Cattle. American Journal of Reproductive Immunology, 67: 224–230. doi: 10.1111/j.1600-0897.2011.01085.x
- Issue published online: 29 JAN 2012
- Article first published online: 30 OCT 2011
- Submitted September 19, 2011; accepted September 26, 2011.
- major histocompatibility complex class I;
- retained placenta
Citation Benedictus L, Thomas AJ, Jorritsma R, Davies CJ, Koets AP. Two-way calf to dam major histocompatibility class I compatibility increases risk for retained placenta in cattle. Am J Reprod Immunol 2012; 67: 224–230
Problem In cattle, retained placenta (RP) is suggested to arise from failure of immune-mediated rejection of the fetal membranes by the maternal immune system and is associated with major histocompatibility (MHC) class I compatibility between calf and dam.
Method of study To study the association between RP and different MHC class I compatibilities between calf–dam–granddam combinations, massively parallel pyrosequencing was used to determine the MHC class I haplotypes of cows with and without RP.
Results Two-way calf to dam MHC class I compatibility gave a high risk for RP. There was a tendency for a higher risk for RP with calf to dam MHC class I compatibility.
Conclusions We concluded that in two-way compatible pregnancies, the maternal immune system fails to reject the fetal membranes, and the fetal immune system does not mount an immune response against maternal MHC class I antigens that could influence the immune-mediated rejection of the fetal membranes by the maternal immune system. The lack of immune-mediated rejection of the fetal membranes by the maternal immune system increases the risk of occurrence of RP.