Both authors contributed equally to the paper.
Heme Oxygenase-1 Expression in the Ovary Dictates a Proper Oocyte Ovulation, Fertilization, and Corpora Lutea Maintenance
Version of Record online: 2 DEC 2011
© 2011 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 67, Issue 5, pages 376–382, May 2012
How to Cite
Zenclussen, M. L., Jensen, F., Rebelo, S., El-Mousleh, T., Casalis, P. A. and Zenclussen, A. C. (2012), Heme Oxygenase-1 Expression in the Ovary Dictates a Proper Oocyte Ovulation, Fertilization, and Corpora Lutea Maintenance. American Journal of Reproductive Immunology, 67: 376–382. doi: 10.1111/j.1600-0897.2011.01096.x
- Issue online: 11 APR 2012
- Version of Record online: 2 DEC 2011
- Submitted November 1, 2011; accepted November 4, 2011.
- fertilzation and corpus luteum;
- heme oxygenase-1;
Citation Zenclussen ML, Jensen F, Rebelo S, El-Mousleh T, Casalis PA, Zenclussen AC. Heme oxygenase-1 expression in the ovary dictates a proper oocyte ovulation, fertilization, and corpora lutea maintenance. Am J Reprod Immunol 2012; 67: 376–382
Problem Animals deficient in Heme oxygenase-1 (HO-1, Hmox1−/− mice) have impaired pregnancies, characterized by intrauterine fetal death. HO-1 expression has been shown to be essential for pregnancy by dictating placentation and intrauterine fetal development. Its absence leads to intrauterine fetal growth restriction and fetal loss, which is independent of the immune system. Defect in previous steps, e.g., ovulation, may, however, also count for their poor reproductive outcome.
Method of study Here, we investigated ovulation after hormonal hyperstimulation in Hmox1 wild-type and knockout animals.
Results and Conclusions We observed that animals lacking HO-1 produced significantly less oocytes after hormonal stimulation than wild type animals and this was mirrored by the number of corpora lutea in the ovary. Furthermore, ovulated oocytes from Hmox1−/− animals were poorly fertilized compared with those from wild-type animals. In conclusion, we demonstrate here that HO-1 plays a pivotal role in the process of oocyte ovulation as well as fertilization, bringing to light a new and unsuspected role for HO-1.