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Serum sTREM-1 (Soluble Triggering Receptor Expressed on Myeloid Cells-1) Associates Negatively with Embryo Quality in Infertility Patients

Authors

  • Kadri Haller-Kikkatalo,

    Corresponding author
    1. Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia
    2. Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia
    3. Women's Clinic, Tartu University Hospital, Tartu, Estonia
    • Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia
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    • These authors contributed equally.
  • Aili Sarapik,

    1. Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia
    2. Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia
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    • These authors contributed equally.
  • Gilbert C. Faure,

    1. Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France
    2. CHU Nancy-Brabois, Vandoeuvre, France
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  • Marie-Christine Béné,

    1. Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France
    2. CHU Nancy-Brabois, Vandoeuvre, France
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  • Frédéric Massin,

    1. Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France
    2. CHU Nancy-Brabois, Vandoeuvre, France
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  • Andres Salumets,

    1. Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia
    2. Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia
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  • Raivo Uibo

    1. Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia
    2. Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia
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Correspondence

Kadri Haller-Kikkatalo, Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Ravila 19, Tartu 50411, Estonia.

E-mail: kadri.haller-kikkatalo@ut.ee

Abstract

Problem

Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a useful biomarker of infection and inflammation.

Method of study

We studied serum and follicular fluid sTREM-1 in infertile patients (N = 110) utilizing enzyme-linked immunosorbent assay.

Results

Serum and follicular sTREM-1 were in good correlation (Pearson's correlation 0.56, P < 0.0001) with higher values in follicular fluid (140.4 ± 34.4 and 115.6 ± 35.1 pg/mL, t-test, P < 0.0001). Endometriosis associated with lower follicular and serum sTREM-1 compared with male factor infertility patients (age-adjusted r = −25.7 pg/mL,P = 0.018; r = −22.1 pg/mL,P = 0.030). No associations between follicular or serum sTREM-1 and clinical parameters were found, except higher serum sTREM-1 associated with lower embryo quality in all patients (adjusted r = −0.3%, P = 0.033), with a cutoff value between 111.5 and 113.3 pg/mL (OR = 0.38, P = 0.048; OR = 0.34, P = 0.028) predicting that more than 39% of embryos would be with good quality.

Conclusion

Serum sTREM-1 could represent a prognostic marker for female fecundity, probably indicating impaired inflammatory reaction of immune system.

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