Cyclooxygenase-2 ( COX -2) Gene-765G/C Polymorphism and Advanced-Stage Endometriosis in Korean Women
Article first published online: 15 MAY 2012
© 2012 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 68, Issue 3, pages 238–243, September 2012
How to Cite
Noronha LE, Antczak DF. Modulation of T-cell reactivity during equine pregnancy is antigen independent. Am J Reprod Immunol 2012; 68: 238–243
- Issue published online: 12 AUG 2012
- Article first published online: 15 MAY 2012
- Manuscript Accepted: 4 APR 2012
- Manuscript Received: 20 DEC 2011
- Cyclooxygenase-2 gene;
We investigated the association of COX -2 gene-765G/C polymorphism and risk of advanced-stage endometriosis in Korean women.
Method of study
This study consisted of 268 women with advanced-stage endometriosis and 242 control women without endometriosis in Korea. Subjects were genotyped for the -765G/C polymorphism of the COX -2 gene by RFLP-PCR analysis.
There were significant differences in the genotype distributions of the -765G/C polymorphism between patients with advanced-stage endometriosis and control subjects. The C allele for -765G/C was associated with significantly lower risk of advanced-stage endometriosis (OR, 0.14; 95% CI, 0.06–0.30).
We have demonstrated a significant genetic association between the -765G/C polymorphism and advanced-stage endometriosis in Korean women. The -765C allele may be protective against the development of the disease in Korean women.