Modulation of T-cell Reactivity During Equine Pregnancy is Antigen Independent
Article first published online: 15 MAY 2012
© 2012 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 68, Issue 2, pages 107–115, August 2012
How to Cite
Citation Noronha LE, Antczak DF. Modulation of T-cell reactivity during equine pregnancy is antigen independent. Am J Reprod Immunol 2012;
- Issue published online: 12 JUL 2012
- Article first published online: 15 MAY 2012
- Manuscript Accepted: 14 APR 2012
- Manuscript Received: 8 JAN 2012
- Zweig Memorial Fund
- US National Institutes of Health. Grant Number: R01 HD049545
- NIH. Grant Number: F32 HD 055794
- cytotoxic T lymphocytes;
- maternal tolerance;
- paternal alloantigen
Pregnant mares demonstrate a reduction in cytotoxic T lymphocyte (CTL) reactivity against cells from the breeding stallion. We investigated whether this effect is limited to activity against paternal major histocompatibility complex (MHC) antigens, and whether it occurs during MHC-compatible pregnancy.
Method of Study
Mares were mated to carry MHC-compatible or MHC-incompatible pregnancies. CTL activity of these mares when pregnant and non-pregnant was measured against cells from horses with MHC haplotypes unrelated to the mare or breeding stallion.
While carrying MHC-incompatible pregnancies, mares demonstrated reduced CTL activity against lymphocytes from third-party horses in addition to those from the breeding stallion. This effect was also observed in mares carrying MHC-compatible pregnancies.
The decrease in maternal T-cell reactivity characteristic of normal equine pregnancy is not restricted to paternal alloantigen, and occurs during MHC-matched matings. This suggests that antigen-independent mechanisms may be responsible for this reduction in cell-mediated immune activity.