Anti-oxidized Low-Density Lipoprotein (oxLDL) Antibody Levels are not Related to Increasing Circulating oxLDL Concentrations During the Course of Pregnancy
Article first published online: 17 MAY 2012
© 2012 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 68, Issue 4, pages 345–352, October 2012
How to Cite
Pecks U, Tillmann D, Ernst S, Maass N, Meinhold-Heerlein I. Anti-oxidized Low Density Lipoprotein (oxLDL) antibody levels are not related to increasing circulating oxLDL concentrations during the course of pregnancy. Am J Reprod Immunol 2012
- Issue published online: 11 SEP 2012
- Article first published online: 17 MAY 2012
- Manuscript Accepted: 16 APR 2012
- Manuscript Revised: 4 APR 2012
- Manuscript Received: 12 JAN 2012
- oxidative stress
To address the question of whether the high levels of oxidative modified low-density lipoproteins (oxLDL) in pregnancy are opposed by an appropriate humoral autoimmune response providing anti-oxLDL autoantibodies in maternal serum of healthy women throughout gestation.
Method of Study
Blood was taken from 33 patients at four different time points from early to late gestation and post-partum. OxLDL and anti-oxLDL concentrations were measured by enzyme-linked immunosorbent assays. ANOVA was used for statistical evaluations followed by post hoc test with Bonferoni adjustment.
Oxidized Low Density Lipoprotein concentrations increased while anti-oxLDL levels decreased significantly from early to late gestation. OxLDL was strongly positively correlated with LDL concentration and mildly negatively associated with anti-oxLDL levels. Estimating the status of oxidation by calculating oxLDL/LDL ratio revealed decreasing values with ongoing pregnancy. Multivariate analysis showed that anti-oxLDL levels were dependent on gestational age but neither on oxLDL levels nor on the oxLDL/LDL ratio.
The results indicate that normal pregnancy is a well-balanced state of oxidative and anti-oxidative processes. However, we could not confirm a dependence of anti-oxLDL autoantibodies on oxLDL concentration. Whether or not the humoral immune system is involved in oxidative defence remains to be elucidated.