PIF* Proprietary: PIF is a patented compound owned by BioIncept, LLC. Dr. Eytan R. Barnea is a (uncompensated) Chief Scientist. Hadassah Hospital – Hebrew University (R.O.) and Yale University (M.J.P.) received an unrestricted grant from BioIncept, LLC.
Pregnancy and Multiple Sclerosis (MS): A Beneficial Association. Possible therapeutic application of embryo-specific Pre-implantation Factor (PIF*)
Article first published online: 17 JUL 2012
© 2012 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 68, Issue 6, pages 456–464, December 2012
How to Cite
Citation Paidas MJ, Annunziato J, Romano M, Weiss L, Or R, Barnea ER. Pregnancy and Multiple Sclerosis (MS): A Beneficial Association. Possible therapeutic application of embryo-specific Pre-implantation Factor (PIF*)Am J Reprod Immunol 2012
- Issue published online: 8 NOV 2012
- Article first published online: 17 JUL 2012
- Manuscript Accepted: 5 JUN 2012
- Manuscript Received: 4 APR 2012
- multiple sclerosis;
- preimplantation factor;
A typical autoimmune neuro-inflammatory disease (NID), multiple sclerosis (MS), is more prevalent in women than in men. Majority of patients with MS are of child-bearing age; therefore, occurrence in pregnancy is common. Herein, we review proposed disease mechanisms and suggest therapeutic interventions, focusing on the remarkable pregnancy-induced protection against MS – insofar considered as best, albeit temporary therapy for such harsh NID. Current drugs used for MS therapy in pregnancy are described. Role of non-pregnancy-specific agents considered involved in amelioration of disease is also presented. This review highlights pregnancy-derived neuro-protective agents, proposing that unique pregnancy-induced immune-protective environment is because of the conceptus and its direct action. The essential role of pre-implantation factor (PIF) in pregnancy is delineated. Finally, PIF immune-modulatory effects and efficacy in chronic model of neuro-inflammation to reduce inflammation and paralysis coupled with neural regeneration is presented. Overall, we postulate that this embryo-derived-compound holds great promise to improve MS and possibly neuro-inflammation in general.