An Analysis of C-Reactive Protein, Procalcitonin, and D-Dimer in Pre-Eclamptic Patients
Article first published online: 11 JUL 2012
© 2012 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 68, Issue 4, pages 331–337, October 2012
How to Cite
Citation Gulec UK, Ozgunen FT, Guzel AB, Buyukkurt S, Seydaoglu G, Urunsak IF, Evruke IC. An analysis of C-reactive protein, procalcitonin, and D-Dimer in pre-eclamptic patients. Am J Reprod Immunol 2012
- Issue published online: 11 SEP 2012
- Article first published online: 11 JUL 2012
- Manuscript Accepted: 6 JUN 2012
- Manuscript Received: 20 APR 2012
- C-reactive protein;
- severe pre-eclampsia;
- systemic inflammatory response syndrome (SIRS)
The aim of this study was to evaluate serum procalcitonin (PCT), C-reactive protein (CRP), and plasma D-Dimer levels in mild and severe pre-eclampsia.
Method of study
Serum PCT, CRP, and D-Dimer levels were analyzed in 64 cases with pre-eclampsia as the study group and 33 healthy pregnant women in the third trimester as the control group. Pre-eclamptic group consisted of mild (n = 31) and severe pre-eclamptic subgroup (n = 33). Laboratory results were compared between the groups and diagnostic usefulness of these parameters were evaluated.
PCT, CRP, and D-Dimer levels were significantly higher in study group than the control group (P = 0.001). PCT, CRP, and D-Dimer were significantly higher in the patients with severe pre-eclampsia than mild pre-eclampsia. There were significant positive correlations between these markers and mean arterial pressure (MAP). Logistic regression analysis using the control and pre-eclampsia group showed that higher PCT (OR, 15.68; 95%-CI, 3.15–78.10), CRP (OR, 14.29; 95%-CI, 3.08–66.34), and D-Dimer levels (OR, 4.97; 95%-CI, 1.22–20.29) were found to be risk factors significantly associated with pre-eclampsia.
This study results confirm that evidence of a possible exaggerated systemic inflammatory response in pre-eclampsia especially in severe pre-eclampsia.