- Top of page
- Clinical Features of GVHD After OLT
- Pathogenesis of GVHD After OLT
- Risk Factors in the Development of GVHD
- Macrochimerism in the Diagnosis of GVHD After OLT
- Prevention of GVHD
- Treatment of GVHD
This article reviews acute graft vs. host disease (GVHD) as a complication of orthotopic liver transplantation (OLT). The incidence, presentation, clinical course and outcome of GVHD after OLT are summarized and the pathogenesis is discussed, drawing parallels with GVHD after allogeneic haematopoietic stem cell transplantation. Risk factors for GVHD after OLT are examined and the potential role of donor lymphocyte macrochimerism in the recipient peripheral blood as a diagnostic aid for GVHD is discussed. Finally, treatment of GVHD after OLT is reviewed with particular emphasis on the potential role of some of the newer biological agents.