• 1
    Liang TB, Man K, Kin-Wah Lee T et al. Distinct intragraft response pattern in relation to graft size in liver transplantation. Transplantation 2003; : 673678.
  • 2
    Kim AH, Khursigara G, Sun X, Franke TF, Chao MV. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 2001; 21: 893901.
  • 3
    Hong F, Nguyen VA, Shen X, Kunos G, Gao B. Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration. Biochem Biophys Res Commun 2000; 279: 974979.
  • 4
    Matsui T, Tao J, Del Monte F et al. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 2001; 104: 330335.
  • 5
    Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 2000; 101: 660667.
  • 6
    Kiuchi M, Adachi K, Kohara T et al. Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols. J Med Chem 2000; 43: 29462961.
  • 7
    Kimura T, Hasegawa T, Nakai H et al. FTY720 reduces T-cell recruitment into murine intestinal allograft and prevents activation of graft-infiltrating cells. Transplantation 2003; 75: 14691474.
  • 8
    Hwang MW, Matsumori A, Furukawa Y et al. FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation. Circulation 1999; 100: 13221329.
  • 9
    Chen S, Bacon KB, Garcia G et al. FTY720, a novel transplantation drug, modulates lymphocyte migratory responses to chemokines. Transplant Proc 2001; 33: 30573063.
  • 10
    Brinkmann V, Davis MD, Heise CE et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002; 277: 2145321457.
  • 11
    Matloubian M, Lo CG, Cinamon G et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004; 427: 355360.
  • 12
    Anselmo DM, Amersi FF, Shen XD et al. FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration. Am J Transplant 2002; 2: 843849.
  • 13
    Troncoso P, Ortiz M, Martinez L, Kahan BD. FTY 720 prevents ischemic reperfusion damage in rat kidneys. Transplant Proc 2001; 33: 857859.
  • 14
    Man K, Lo CM, Ng IO et al. Liver transplantation in rats using small-for-size grafts: a study of hemodynamic and morphological changes. Arch Surg 2001; 136: 280285.
  • 15
    Man K, Fan ST, Lo CM et al. Graft injury in relation to graft size in right lobe live donor liver transplantation: a study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression. Ann Surg 2003; 237: 256264.
  • 16
    Man K, Lo CM, Lee TK, Li XL, Ng IO, Fan ST. Intragraft gene expression profiles by cDNA microarray in small-for-size liver grafts. Liver Transpl 2003; 9: 425432.
  • 17
    Lo CM, Liu CL, Fan ST. Portal hyperperfusion injury as the cause of primary nonfunction in a small-for-size liver graft-successful treatment with splenic artery ligation. Liver Transpl 2003; 9: 626628.
  • 18
    Man K, Lee TK, Liang TB et al. FK409 ameliorates small-for-size graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway. Ann Surg, 2004, in press.
  • 19
    Luo Z, Fujio Y, Kureishi Y et al. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. J Clin Invest 2000; 106: 493499.
  • 20
    Scotland RS, Morales-Ruiz M, Chen Y et al. Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res 2002; 90: 904910.
  • 21
    Mashimo H, Goyal RK. Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice. Am J Physiol 1999; 277: G745G750.
  • 22
    Lo LW, Cheng JJ, Chiu JJ, Wung BS, Liu YC, Wang DL. Endothelial exposure to hypoxia induces Egr-1 expression involving PKCalpha-mediated Ras/Raf-1/ERK1/2 pathway. J Cell Physiol 2001; 188: 304312.
  • 23
    Jones N, Agani FH. Hyperoxia induces Egr-1 expression through activation of extracellular signal-regulated kinase 1/2 pathway. J Cell Physiol 2003; 196: 326333.
  • 24
    Sass G, Koerber K, Bang R, Guehring H, Tiegs G. Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J Clin Invest 2001; 107: 439447.
  • 25
    Smyrniotis VE, Kostopanagiotou G, Theodoraki K et al. Effect of mesocaval shunt on survival of small-for-size liver grafts: experimental study in pigs. Transplantation 2003; 75: 17371740.
  • 26
    Tawadrous MN, Zimmermann A, Zhang XY, Wheatley AM. Persistence of impaired hepatic microcirculation after nonarterialized liver transplantation in the rat. Microcirculation 2002; 9: 363375.