• 1
    Sykes M, Sachs DH. Mixed allogeneic chimerism as an approach to transplantation tolerance. Immunol Today 1988; 9: 237. [Erratum appeared in Immunol Today, 1988; 9: 131].
  • 2
    Sachs DH. Mixed chimerism as an approach to transplantation tolerance. Clin Immunol 2000; 95: S63S68.
  • 3
    Buhler L, Awwad M, Treter S et al. Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. [See comment]. Transplantation 2002; 73: 1222.
  • 4
    Buhler LH, Spitzer TR, Sykes M et al. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation 2002; 74: 14051409.
  • 5
    Fuchimoto Y, Huang CA, Yamada K et al. Induction of kidney allograft tolerance through mixed chimerism in miniature swine. Transplant Proc 2001; 33: 77.
  • 6
    Chapman LE, Folks TM, Salomon DR, Patterson AP, Eggerman TE, Noguchi PD. Xenotransplantation and xenogeneic infections. N Engl J Med 1995; 333: 14981501.
  • 7
    Fishman JA. Xenosis and xenotransplantation: addressing the infectious risks posed by an emerging technology. Kidney Int 1997; 58: S41S45.
  • 8
    Bach FH, Fishman JA, Daniels N et al. Uncertainty in xenotransplantation: individual benefit versus collective risk.[comment]. Nat Med 1998; 4: 141144.
  • 9
    Fishman JA. Infection and xenotransplantation. Developing strategies to minimize risk. Ann N Y Acad Sci 1998; 862: 5266.
  • 10
    Michaels MG, Jenkins FJ, St George K, Nalesnik MA, Starzl TE, Rinaldo CR Jr. Detection of infectious baboon cytomegalovirus after baboon-to-human liver xenotransplantation. J Virol 2001; 75: 28252828.
  • 11
    Michaels MG, McMichael JP, Brasky K et al. Screening donors for xenotransplantation. The potential for xenozoonoses. Transplantation 1994; 57: 14621465.
  • 12
    Fishman JA, Rubin RH. Infection in organ-transplant recipients. see comment. N Engl J Med 1998; 338: 17411751.
  • 13
    Fishman JA. The risk of infection in xenotransplantation. Introduction. Ann N Y Acad Sci 1998; 862: 4551.
  • 14
    Robinson D, Liu JL, Jones D et al. Avian leukemias and lymphomas: interplay between retroviruses and herpesviruses. Leukemia 1997; 11: 176178.
  • 15
    Isfort RJ, Witter R, Kung HJ. Retrovirus insertion into herpesviruses. Trend Microbiol 1994; 2: 174177.
  • 16
    Isfort R, Jones D, Kost R, Witter R, Kung HJ. Retrovirus insertion into herpesvirus in vitro and in vivo. Proc Nat Acad Sci USA 1992; 89: 991995.
  • 17
    Javier RT, Sedarati F, Stevens JG. Two avirulent herpes simplex viruses generate lethal recombinants in vivo. Science 1986; 234: 746748.
  • 18
    Akiyoshi DE, Denaro M, Zhu H, Greenstein JL, Banerjee P, Fishman JA. Identification of a full-length cDNA for an endogenous retrovirus of miniature swine. J Virol 1998; 72: 45034507.
  • 19
    Patience C, Takeuchi Y, Weiss RA. Infection of human cells by an endogenous retrovirus of pigs. [see comment]. Nat Med 1997; 3: 282286.
  • 20
    Takeuchi Y, Patience C, Magre S et al. Host range and interference studies of three classes of pig endogenous retrovirus. J Virol 1998; 72: 99869991.
  • 21
    Mueller NJ, Barth RN, Yamamoto S et al. Activation of cytomegalovirus in pig-to-primate organ xenotransplantation. J Virol 2002; 76: 47344740.
  • 22
    Fryer JF, Griffiths PD, Fishman JA, Emery VC. Clark DA. Quantitation of porcine cytomegalovirus in pig tissues by PCR. J Clin Microbiol 2001; 39: 11551156.
  • 23
    Huang CA, Fuchimoto Y, Gleit ZL et al. Posttransplantation lymphoproliferative disease in miniature swine after allogeneic hematopoietic cell transplantation: similarity to human PTLD and association with a porcine gammaherpesvirus. Blood 2001; 97: 14671473.
  • 24
    Goltz M, Ericsson T, Patience C et al. Sequence analysis of the genome of porcine lymphotropic herpesvirus 1 and gene expression during posttransplant lymphoproliferative disease of pigs. Virology 2002; 294: 383393.
  • 25
    Chmielewicz B, Goltz M, Franz T et al. A novel porcine gammaherpesvirus. Virology 2003; 308: 317329.
  • 26
    Cooper DK, Good AH, Koren E et al. Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man. Transplant Immunol 1993; 1: 198205.
  • 27
    Cooper DK, Koren E, Oriol R. Oligosaccharides and discordant xenotransplantation. Immunol Rev 1994; 141: 3158.
  • 28
    Bracy JL, Cretin N, Cooper DK, Iacomini J. Xenoreactive natural antibodies. Cell Mol Life Sci 1999; 56: 10011007.
  • 29
    Platt JL. The prospects for xenotransplantation of the kidney. Curr Opin Nephrol Hyper 1997; 6: 284291.
  • 30
    Platt JL. Current status of xenotransplantation: research and technology. Transplant Proc 1998; 30: 16301633.
  • 31
    Samstein B, Platt JL. Physiologic and immunologic hurdles to xenotransplantation. J Am Soc Nephrol 2001; 12: 182193.
  • 32
    Platt JL. Genetic engineering for xenotransplantation. Transplant Proc 1999; 31: 14881490.
  • 33
    Weiss RA. Cross-species infections. Current Topics Microbiol Immunol 2003; 278: 4771.
  • 34
    Lai L, Kolber-Simonds D, Park KW et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295: 10891092.
  • 35
    Fishman JA. Transplantation for patients infected with human immunodeficiency virus: no longer experimental but not yet routine. [comment]. J Infect Dis 2003; 188: 14051411.
  • 36
    Patience C, Switzer WM, Takeuchi Y et al. Multiple groups of novel retroviral genomes in pigs and related species. J Virol 2001; 75: 27712775.
  • 37
    Klymiuk N, Muller M, Brem G, Aigner B. Characterization of porcine endogenous retrovirus gamma pro-pol nucleotide sequences. J Virol 2002; 76: 1173811743.
  • 38
    Oldmixon BA, Wood JC, Ericsson TA et al. Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine. J Virol 2002; 76: 30453048.
  • 39
    Ericsson TA, Takeuchi Y, Templin C et al. Identification of receptors for pig endogenous retrovirus. Proc Nat Acad Sci USA 2003; 100: 67596764.
  • 40
    Denner J, Specke V, Schwendemann J, Tacke SJ. Porcine endogenous retroviruses (PERVs). adaptation to human cells and attempts to infect small animals and non-human primates. Ann Transplant 2001; 6: 2533.
  • 41
    Specke V, Rubant S, Denner J. Productive infection of human primary cells and cell lines with porcine endogenous retroviruses. Virology 2001; 285: 177180.
  • 42
    Tonjes RR, Czauderna F, Fischer N et al. Molecularly cloned porcine endogenous retroviruses replicate on human cells. Transplant Proc 2000; 32: 11581161.
  • 43
    Wilson CA, Wong S, VanBrocklin M, Federspiel MJ. Extended analysis of the in vitro tropism of porcine endogenous retrovirus. J Virol 2000; 74: 4956.
  • 44
    Martin U, Steinhoff G, Kiessig V et al. Porcine endogenous retrovirus is transmitted neither in vivo nor in vitro from porcine endothelial cells to baboons. Transplant Proc 1999; 31: 913914.
  • 45
    Martin U, Kiessig V, Blusch JH et al. Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells. [See comment]. Lancet 1998; 352: 692694.
  • 46
    Blusch JH, Patience C, Takeuchi Y et al. Infection of nonhuman primate cells by pig endogenous retrovirus. J Virol 2000; 74: 76877690.
  • 47
    Wilson CA, Wong S, Muller J, Davidson CE, Rose TM, Burd P. Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells. J Virol 1998; 72: 30823087.
  • 48
    Scobie L, Taylor S, Wood JC et al. Absence of replication-competent human-tropic porcine endogenous retroviruses in the germ line DNA of inbred miniature swine. J Virol 2004; 78: 25022509.
  • 49
    Le Tissier P, Stoye JP, Takeuchi Y, Patience C, Weiss RA. Two sets of human-tropic pig retrovirus. Nature 1997; 389: 681682.
  • 50
    Martin U, Winkler ME, Id M et al. Productive infection of primary human endothelial cells by pig endogenous retrovirus (PERV). Xenotransplantation 2000; 7: 138142.
  • 51
    Patience C, Patton GS, Takeuchi Y et al. No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys. See comment. Lancet 1998; 352: 699701.
  • 52
    Paradis K, Langford G, Long Z et al. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study Group. [Comment]. Science 1999; 285: 12361241.
  • 53
    Heneine W, Tibell A, Switzer WM et al. No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts. [Comment]Lancet 1998; 352: 695699. [Erratum appearsed in Lancet, 1998; 352: 1478].
  • 54
    Cunningham DA, Herring C, Fernandez-Suarez XM, Whittam AJ, Paradis K, Langford GA. Analysis of patients treated with living pig tissue for evidence of infection by porcine endogenous retroviruses. Trend Cardio Med 2001; 11: 190196.
  • 55
    Wilhelm M, Fishman JA, Pontikis R, Aubertin AM, Wilhelm FX. Susceptibility of recombinant porcine endogenous retrovirus reverse transcriptase to nucleoside and non-nucleoside inhibitors. Cell Mol Life Sci 2002; 59: 21842190.
  • 56
    Ritzhaupt A, Van Der Laan LJ, Salomon DR, Wilson CA. Porcine endogenous retrovirus infects but does not replicate in nonhuman primate primary cells and cell lines. J Virol 2002; 76: 1131211320.
  • 57
    Gollackner B, Mueller NJ, Houser S et al. Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation. Transplantation 2003; 75: 18411847.
  • 58
    Mueller NJ, Knosalla C, Kuwaki K et al. Exclusion of porcine cytomegalovirus in pig-to-primate xenotransplantation prevents consumptive coagulopathy and is associated with prolonged graft survival. Transplantation (in press).
  • 59
    Mueller N, Sulling K, Gollackner B et al. Reduced Efficacy of ganciclovir against Porcine and Baboon Cytomegalovirus in pig-to-baboon xenotransplantation. Am J Transplant 2003; 3: 10571064.
  • 60
    Ulrich S, Goltz M, Ehlers B. Characterization of the DNA polymerase loci of the novel porcine lymphotropic herpesviruses 1 and 2 in domestic and feral pigs. J Gen Virol 1999; 80: 31993205.
  • 61
    Mueller NJ, Livingston C, Knosalla C et al. Activation of porcine cytomegalovirus but not porcine lymphrotrophic herpesvirus in pig-to-baboon xenotransplantation. J Infect Dis 2004; 189: 16281633.
  • 62
    Groth CG, Andersson A, Korsgren O et al. Transplantation of porcine fetal islet-like cell clusters into eight diabetic patients. Transplant Proc 1993; 25: 970.
  • 63
    Bjoersdorff A, Korsgren O, Andersson A, Tollemar J, Malmborg AS, Ehrnst Groth CG. Microbiologic screening as a preparatory step for clinical xenografting of porcine fetal islet-like cell clusters. Transplant Proc 1992; 24: 674676.
  • 64
    Kumagai Braesch M, Groth CG, Korsgren O et al. Immune response of diabetic patients against transplanted porcine fetal islet cells. Transplant Proc 1992; 24: 679680.
  • 65
    Groth CG, Korsgren O, Andersson A et al. Evidence of xenograft function in a diabetic patient grafted with porcine fetal pancreas. Transplant Proc 1992; 24: 972973.
  • 66
    Fink JS, Schumacher JM, Ellias SL et al. Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results. Cell Transplant 2000; 9: 273278.
  • 67
    Schumacher JM, Ellias SA, Palmer EP et al. Transplantation of embryonic porcine mesencephalic tissue in patients with PD. Neurology 2000; 54: 10421050.
  • 68
    Fishman J. Infection in xenotransplantation – assessing the risks of novel technology. In: BowdenRA, Ljungman P, PayaC, eds. Transplant Infections, 2nd edn. Hagerstown , MD : Lippincott: Williams & Wilkins, 2003: 687698.
  • 69
    Olsen CW, Brammer L, Easterday BC et al. Serologic evidence of H1 swine Influenza virus infection in swine farm residents and employees. Emerg Infect Dis 2002; 8: 814819.
  • 70
    Olsen CW. The emergence of novel swine influenza viruses in North America. Virus Res 2002; 85: 199210.
  • 71
    Prevention CfDCa. Influenza update – United States swine influenza-like isolate – Nevada. MMWR 1982; 31: 195197.
  • 72
    Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. Evolution and ecology of influenza A viruses. Microbiol Rev 1992; 56: 152179.
  • 73
    Campitelli L, Donatelli I, Foni E et al. Continued evolution of H1N1 and H3N2 influenza viruses in pigs in Italy. Virology 1997; 232: 310318.
  • 74
    Kawaoka Y, Gorman OT, Ito T et al. Influence of host species on the evolution of the nonstructural (NS) gene of influenza A viruses. Virus Res 1998; 55: 143156.
  • 75
    Zhou NN. Senne DA, Landgraf JS et al. Genetic reassortment of avian, swine, and human influenza A viruses in American pigs. J Virol 1999; 73: 88518856.
  • 76
    Widdowson MA, Jaspers WJ, Van Der Poel WH et al. Cluster of cases of acute hepatitis associated with hepatitis E virus infection acquired in the Netherlands. Clin Infect Dis 2003; 36: 2933.
  • 77
    Van Der Poel WH, Verschoor F, Van Der Heide R et al. Hepatitis E virus sequences in swine related to sequences in humans, The Netherlands. Emerg Infect Dis 2001; 7: 970976.
  • 78
    Michaels MG, Lanford R, Demetris AJ et al. Lack of susceptibility of baboons to infection with hepatitis B virus. Transplantation 1996; 61: 350351.