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A Novel Model for Post-Transplant Obliterative Airway Disease Reveals Angiogenesis from the Pulmonary Circulation
Article first published online: 11 NOV 2004
DOI: 10.1111/j.1600-6143.2004.00680.x
Additional Information
How to Cite
Dutly, A. E., Andrade, C. F., Verkaik, R., Kugathasan, L., Trogadis, J., Liu, M., Waddell, T. K., Stewart, D. J. and Keshavjee, S. (2005), A Novel Model for Post-Transplant Obliterative Airway Disease Reveals Angiogenesis from the Pulmonary Circulation. American Journal of Transplantation, 5: 248–254. doi: 10.1111/j.1600-6143.2004.00680.x
Publication History
- Issue published online: 11 NOV 2004
- Article first published online: 11 NOV 2004
- Received 7 April 2004, revised and accepted for publication 3 September 2004
- Abstract
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Keywords:
- Angiogenesis;
- bronchiolitis obliterans;
- pulmonary circulation
We present a novel animal model for post-transplant obliterative airway disease in which the donor trachea is implanted into the recipient's lung parenchyma. Although this procedure is technically more challenging than the heterotopic model of implantation into a subcutaneous pouch, it has several important advantages some of which are the appropriate local environment and the possibility of local immunosuppressive therapy after transtracheal gene, cell or drug delivery. This model has revealed new insights into angiogenic potential of the pulmonary circulation.