• 1
    Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 2000; 342: 605612.DOI: 10.1056/NEJM200003023420901
  • 2
    Opelz G. Influence of treatment with cyclosporine, azathioprine and steroids on chronic allograft failure. The Collaborative Transplant Study. Kidney Int Suppl 1995; 52: S89S92.
  • 3
    Soulillou JP, Giral M. Controlling the incidence of infection and malignancy by modifying immunosuppression. Transplantation 2001; 72(12 Suppl.): S89S93.DOI: 10.1097/00007890-200107150-00018
  • 4
    Giral M, Pascuariello G, Karam G et al. Acute graft pyelonephritis and long-term kidney allograft outcome. Kidney Int 2002; 61: 18801886.DOI: 10.1046/j.1523-1755.2002.00323.x
  • 5
    Dantal J, Hourmant M, Cantarovich D et al. Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens. Lancet 1998; 351: 623628.DOI: 10.1016/S0140-6736(97)08496-1
  • 6
    Strober S, Benike C, Krishnaswamy S, Engleman EG, Grumet FC. Clinical transplantation tolerance twelve years after prospective withdrawal of immunosuppressive drugs: studies of chimerism and anti-donor reactivity. Transplantation 2000; 69: 15491554.DOI: 10.1097/00007890-200004270-00005
  • 7
    Jacobsen N, Taaning E, Ladefoged J, Kristensen JK, Pedersen FK. Tolerance to an HLA-B, DR disparate kidney allograft after bone-marrow transplantation from same donor. Lancet 1994; 343: 800.DOI: 10.1016/S0140-6736(94)91881-3
  • 8
    Burlingham WJ, Grailer AP, Fechner JH, Jr. et al. Microchimerism linked to cytotoxic T lymphocyte functional unresponsiveness (clonal anergy) in a tolerant renal transplant recipient. Transplantation 1995; 59: 11471155.
  • 9
    Zoller KM, Cho SI, Cohen JJ, Harrington JT. Cessation of immunosuppressive therapy after successful transplantation: a national survey. Kidney Int 1980; 18: 110114.
  • 10
    VanBuskirk AM, Burlingham WJ, Jankowska-Gan E et al. Human allograft acceptance is associated with immune regulation. J Clin Invest 2000; 106: 145155.
  • 11
    Ciubotariu R, Liu Z, Colovai AI et al. Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts. J Clin Invest 1998; 101: 398405.
  • 12
    Douillard P, Pannetier C, Josien R et al. Donor-specific blood transfusion-induced tolerance in adult rats with a dominant TCR-Vbeta rearrangement in heart allografts. J Immunol 1996; 157: 12501260.
  • 13
    Brouard S, Vanhove B, Gagne K et al. T cell repertoire alterations of vascularized xenografts. J Immunol 1999; 162: 33673377.
  • 14
    Pannetier C, Even J, Kourilsky P. T cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol Today 1995; 16: 176181.DOI: 10.1016/0167-5699(95)80117-0
  • 15
    Gorochov G, Neumann AU, Kereveur A et al. Perturbation of CD4+ and CD8+ T cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nat Med 1998; 4: 215221.DOI: 10.1038/nm0298-215
  • 16
    Sebille F, Gagne K, Guillet M et al. Direct recognition of foreign MHC determinants by naive T cells mobilizes specific Vbeta families without skewing of the complementarity-determining region 3 length distribution. J Immunol 2001; 167: 30823088.
  • 17
    Guillet M, Sebille F, Soulillou J. TCR usage in naive and committed alloreactive cells: implications for the understanding of TCR biases in transplantation. Curr Opin Immunol 2001; 13: 566571.DOI: 10.1016/S0952-7915(00)00260-0
  • 18
    Josien R, Heslan M, Brouard S, Soulillou JP, Cuturi MC. Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion. Blood 1998; 92: 45394544.
  • 19
    Waldmann H, Cobbold S. Regulating the immune response to transplants. a role for CD4+ regulatory cells? Immunity 2001; 14: 399406.DOI: 10.1016/S1074-7613(01)00120-0
  • 20
    Zhai Y, Li J, Hammer M, Busuttil RW, Volk HD, Kupiec-Weglinski JW. Evidence of T cell clonality in the infectious tolerance pathway: implications toward identification of regulatory T cells. Transplantation 2001; 71: 17011708.DOI: 10.1097/00007890-200106270-00001
  • 21
    Baron C, McMorrow I, Sachs DH, LeGuern C. Persistence of dominant T cell clones in accepted solid organ transplants. J Immunol 2001; 167: 41544160.
  • 22
    Baron C, Sachs DH, LeGuern C. A particular TCR beta variable region used by T cells infiltrating kidney transplants. J Immunol 2001; 166: 25892596.
  • 23
    Guillet M, Brouard S, Gagne K et al. Different qualitative and quantitative regulation of Vbeta TCR transcripts during early acute allograft rejection and tolerance induction. J Immunol 2002; 168: 50885095.
  • 24
    Schwartz RH. Models of T cell anergy: is there a common molecular mechanism? J Exp Med 1996; 184: 18.DOI: 10.1084/jem.184.1.1
  • 25
    Douillard P, Vignes C, Josien R et al. Reassessment of the role of CD8+ T cells in the induction of allograft tolerance by donor-specific blood transfusion. Eur J Immunol 1999; 29: 19191924.DOI: 10.1002/(SICI)1521-4141(199906)29:06<1919::AID-IMMU1919>3.3.CO;2-#
  • 26
    Ciubotariu R, Vasilescu R, Ho E et al. Detection of T suppressor cells in patients with organ allografts. Hum Immunol 2001; 62: 1520.
  • 27
    Vella JP, Spadafora-Ferreira M, Murphy B et al. Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction. Transplantation 1997; 64: 795800.DOI: 10.1097/00007890-199709270-00001
  • 28
    Schwab R, Szabo P, Manavalan JS et al. Expanded CD4+ and CD8+ T cell clones in elderly humans. J Immunol 1997; 158: 44934499.
  • 29
    Ku CC, Kappler J, Marrack P. Characteristics and maintenance of CD8+ T cell clones found in old mice. Mech Ageing Dev 1997; 94: 4153.DOI: 10.1016/S0047-6374(96)01865-9
  • 30
    Ku CC, Kappler J, Marrack P. The growth of the very large CD8+ T cell clones in older mice is controlled by cytokines. J Immunol 2001; 166: 21862193.
  • 31
    Colombatti A, Doliana R, Schiappacassi M, et al. Age-related persistent clonal expansions of CD28- cells: phenotypic and molecular TCR analysis reveals both CD4+ and CD4+CD8+ cells with identical CDR3 sequences. Clin Immunol Immunopathol 1998; 89: 6170.
  • 32
    Ricalton NS, Roberton C, Norris JM, Rewers M, Hamman RF, Kotzin BL. Prevalence of CD8+ T cell expansions in relation to age in healthy individuals. J Gerontol A Biol Sci Med Sci 1998; 53: B196B203.
  • 33
    Halapi E, Jeddi-Tehrani M, Blucher A et al. Diverse T-cell receptor CDR3 length patterns in human CD4+ and CD8+ T lymphocytes from newborns and adults. Scand J Immunol 1999; 49: 149154.DOI: 10.1046/j.1365-3083.1999.00469.x
  • 34
    Ginaldi L, De Martinis M, D'Ostilio A, Marini L, Loreto MF, Quaglino D. Immunological changes in the elderly. Aging (Milano) 1999; 11: 281286.
  • 35
    Marrack P, Lo D, Brinster R et al. The effect of thymus environment on T cell development and tolerance. Cell 1988; 53: 627634.
  • 36
    Strom TB, Tilney NL, Carpenter CB, Busch GJ. Identity and cytotoxic capacity of cells infiltrating renal allografts. N Engl J Med 1975; 292: 12571263.
  • 37
    Thomson AW, Mazariegos GV, Reyes J et al. Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients. Transplantation 2001; 72(8 Suppl.): S13S22.DOI: 10.1097/00007890-200107150-00006