1600-6143/asset/olbannerleft.gif?v=1&s=c46a3f174bfd9c6eb548cc809401524372c32e90)
1600-6143/asset/olbannerright.gif?v=1&s=9fc9790fa8ad5ef85aeaf408bf0d3d969d2fc012)
Is Liver Transplantation Advisable for Isoniazid Fulminant Hepatitis in Active Extrapulmonary Tuberculosis?
Article first published online: 12 AUG 2005
DOI: 10.1111/j.1600-6143.2005.01065.x
Additional Information
How to Cite
Barcena, R., Oton, E., Moreno, M. A., Fortún, J., Garcia-Gonzalez, M., Moreno, A. and De Vicente, E. (2005), Is Liver Transplantation Advisable for Isoniazid Fulminant Hepatitis in Active Extrapulmonary Tuberculosis?. American Journal of Transplantation, 5: 2796–2798. doi: 10.1111/j.1600-6143.2005.01065.x
Publication History
- Issue published online: 12 AUG 2005
- Article first published online: 12 AUG 2005
- Received 4 April 2005, revised and accepted for publication 4 July 2005
- Abstract
- Article
- References
- Cited By
Keywords:
- Infection;
- liver failure;
- liver transplantation;
- toxicity
Antituberculous treatment is a well-known cause of fulminant hepatic failure (FHF). This could lead to liver transplantation as the only possible treatment, which on the other hand could be contraindicated due to active tuberculosis. The risk of aggressive dissemination of the disease after transplantation is not clearly determined by the current second-line antituberculous therapies. We report a case of vertebral tuberculosis treated with rifampin, isoniazid and pyrazinamide. He developed an FHF that was treated with urgent liver transplantation. Despite the immunosuppression, the disease was well controlled with ciprofloxacin, ethambutol and streptomycin and the patient is in good health 23 months after transplantation. In conclusion, active extrapulmonary tuberculosis should perhaps be considered for liver transplantation when FHF develops due to anti-tuberculous drugs.