• 1
    Man K, Lo CM, Ng IO et al. Liver transplantation in rats using small-for-size grafts: A study of hemodynamic and morphological changes. Arch Surg 2001; 136: 280285.
  • 2
    Man K, Lo CM, Lee TK, Li XL, Ng IO, Fan ST. Intragraft gene expression profiles by cDNA microarray in small-for-size liver grafts. Liver Transpl 2003; 9: 425432.
  • 3
    Man K, Fan ST, Lo CM et al. Graft injury in relation to graft size in right lobe live donor liver transplantation: A study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression. Ann Surg 2003; 237: 256264.
  • 4
    Man K, Lee TK, Liang TB et al. FK 409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway. Ann Surg 2004; 240: 159168.
  • 5
    Zhao Y, Man K, Lo CM et al. Attenuation of small-for-size liver graft injury by FTY720: Significance of cell-survival Akt signaling pathway. Am J Transplant 2004; 4: 13991407.
  • 6
    Yee HF. Rho directs activation-associated changes in rat hepatic stellate cell morphology via regulation of the actin cytoskeleton. Hepatology 1998; 28: 843850.
  • 7
    Kato M, Iwamoto H, Higashi N et al. Role of Rho small GTP binding protein in the regulation of actin cytoskeleton in hepatic stellate cells. J Hepatol 1999; 31: 9199.
  • 8
    Murata T, Arii S, Nakamura T et al. Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells. J Hepatol 2001; 35: 474481.
  • 9
    Tada S, Iwamoto H, Nakamuta M et al. A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats. J Hepatol 2001; 34: 529536.
  • 10
    Mizunuma K, Ohdan H, Tashiro H, Fudaba Y, Ito H, Asahara T. Prevention of ischemia-reperfusion-induced hepatic microcirculatory disruption by inhibiting stellate cell contraction using rock inhibitor. Transplantation 2003; 75: 579586.
  • 11
    Viklicky O, Bohmova R, Ouyang N et al. Effect of sirolimus on renal ischaemia/reperfusion injury in normotensive and hypertensive rats. Transpl Int 2004; 17: 432441.
  • 12
    Bohmova R, Honsova E, Heemann U et al. Effect of sirolimus on ischemia/reperfusion injury in transgenic hypertensive rat. Transplant Proc 2002; 34: 30513052.
  • 13
    Guerin P, Sauzeau V, Rolli-Derkinderen M et al. Stent implantation activates RhoA in human arteries: Inhibitory effect of rapamycin. J Vasc Res 2005; 42: 2128.
  • 14
    Zhu J, Wu J, Frizell E et al. Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology 1999; 117: 11981204.
  • 15
    Tzima E, Del Pozo MA, Kiosses WB et al. Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J 2002; 21: 67916800.
  • 16
    Ikeda F, Terajima H, Shimahara Y, Kondo T, Yamaoka Y. Reduction of hepatic ischemia/reperfusion-induced injury by a specific ROCK/Rho kinase inhibitor Y-27632. J Surg Res 2003; 109: 155160.
  • 17
    Thimgan MS, Yee HF, Jr. Quantitation of rat hepatic stellate cell contraction: Stellate cells' contribution to sinusoidal resistance. Am J Physiol 1999; 277(1 Pt 1): G137G143.
  • 18
    Yoshiji H, Kuriyama S, Yoshii J et al. Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis. Gut 2003; 52: 13471354.
  • 19
    Braide M, Amundson B, Chien S, Bagge U. Quantitative studies on the influence of leukocytes on the vascular resistance in a skeletal muscle preparation. Microvasc Res 1984; 27: 331352.
  • 20
    Kawada N, Seki S, Kuroki T, Kaneda K. ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1. Biochem Biophys Res Commun 1999; 266: 296300.
  • 21
    Torsoni AS, Marin TM, Velloso LA, Franchini KG. Rhoa/ROCK signaling is critical to FAK activation by cycling stretch in cardiac myocytes. Am J Physiol Heart Circ Physiol 2005; 289: 14881496.
  • 22
    Wilkinson S, Paterson HF, Marshall CJ. Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat Cell Biol 2005; 7: 255261.
  • 23
    Croft DR, Sahai E, Mavria G et al. Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Res 2004; 64: 89949001.
  • 24
    Corpechot C, Barbu V, Wendum D et al. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology 2002; 35: 10101021.
  • 25
    Takamura M, Sakamoto M, Genda T, Ichida T, Asakura H, Hirohashi S. Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632. Hepatology 2001; 33: 577581.
  • 26
    Guba M, Von BP, Steinbauer M et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med 2002; 8: 128135.