Note on sources: The articles in this report are based on the reference tables in the 2005 OPTN/SRTR Annual Report, which are not included in this publication. Many relevant data appear in the figures and tables included here; other tables from the Annual Report that serve as the basis for this article include the following: Tables 1.5, 5.2, 5.8–5.11, 6.2, 6.8–6.11, 7.2, 7.8–7.11, 8.2, 8.8–8.11, 9.8–9.11, 10.2, 10.8–10.11, 11.8–11.11, 12.2, 12.8–12.11, 13.2 and 13.8–13.11. All of these tables may be found online at http://www.ustransplant.org.
Analytical Methods and Database Design: Implications for Transplant Researchers, 2005
Version of Record online: 5 APR 2006
American Journal of Transplantation
Volume 6, Issue 5p2, pages 1228–1242, May 2006
How to Cite
Levine, G. N., McCullough, K. P., Rodgers, A. M., Dickinson, D. M., Ashby, V. B. and Schaubel, D. E. (2006), Analytical Methods and Database Design: Implications for Transplant Researchers, 2005. American Journal of Transplantation, 6: 1228–1242. doi: 10.1111/j.1600-6143.2006.01277.x
- Issue online: 5 APR 2006
- Version of Record online: 5 APR 2006
- statistical analysis;
- survival analysis;
- data collection;
- data sources;
- data structure;
- death ascertainment;
- transplant research
Understanding how transplant data are collected is crucial to understanding how the data can be used. The collection and use of Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) data continues to evolve, leading to improvements in data quality, timeliness and scope while reducing the data collection burden. Additional ascertainment of outcomes completes and validates existing data, although caveats remain for researchers. We also consider analytical issues related to cohort choice, timing of data submission, and transplant center variations in follow-up data. All of these points should be carefully considered when choosing cohorts and data sources for analysis.
The second part of the article describes some of the statistical methods for outcome analysis employed by the SRTR. Issues of cohort and follow-up period selection lead into a discussion of outcome definitions, event ascertainment, censoring and covariate adjustment. We describe methods for computing unadjusted mortality rates and survival probabilities, and estimating covariate effects through regression modeling. The article concludes with a description of simulated allocation modeling, developed by the SRTR for comparing outcomes of proposed changes to national organ allocation policies.