• 1
    Lange PA, Stoller JK. The hepatopulmonary syndrome. Ann Intern Med 1995; 122: 521529.
  • 2
    Hoeper MM, Krowka MJ, Strassburg CP. Portopulmonary hypertension and hepatopulmonary syndrome. Lancet 2004; 363: 14611468.
  • 3
    Fallon MB, Abrams GA. Pulmonary dysfunction in chronic liver disease. Hepatology 2000; 32: 859865.
  • 4
    Schenk P, Schoniger-Hekele M, Fuhrmann V, Madl C, Silberhumer G, Muller C. Prognostic significance of the hepatopulmonary syndrome in patients with cirrhosis. Gastroenterology 2003; 125: 10421052.
  • 5
    Gomez FP, Martinez-Palli G, Barbera JA, Roca J, Navasa M, Rodriguez-Roisin R. Gas exchange mechanism of orthodeoxia in hepatopulmonary syndrome. Hepatology 2004; 40: 660666.
  • 6
    Rodriguez-Roisin R, Roca J, Agusti AG, Mastai R, Wagner PD, Bosch J. Gas exchange and pulmonary vascular reactivity in patients with liver cirrhosis. Am Rev Respir Dis 1987; 135: 10851092.
  • 7
    Epstein SK, Zilberberg MD, Jacoby C, Ciubotaru RL, Kaplan LM. Response to symptom-limited exercise in patients with the hepatopulmonary syndrome. Chest 1998; 114: 736741.
  • 8
    Agusti AG, Roca J, Rodriguez-Roisin R, Mastai R, Wagner PD, Bosch J. Pulmonary hemodynamics and gas exchange during exercise in liver cirrhosis. Am Rev Respir Dis 1989; 139: 485491.
  • 9
    Cremona G, Higenbottam TW, Mayoral V et al. Elevated exhaled nitric oxide in patients with hepatopulmonary syndrome. Eur Respir J 1995; 8: 18831885.
  • 10
    Rolla G, Brussino L, Colagrande P et al. Exhaled nitric oxide and oxygenation abnormalities in hepatic cirrhosis. Hepatology 1997; 26: 842847.
  • 11
    Rolla G. Hepatopulmonary syndrome: Role of nitric oxide and clinical aspects. Dig Liver Dis 2004; 36: 303308.
  • 12
    Rolla G, Brussino L, Colagrande P et al. Exhaled nitric oxide and impaired oxygenation in cirrhotic patients before and after liver transplantation. Ann Intern Med 1998; 129: 375378.
  • 13
    Battaglia SE, Pretto JJ, Irving LB, Jones RM, Angus PW. Resolution of gas exchange abnormalities and intrapulmonary shunting following liver transplantation. Hepatology 1997; 25: 12281232.
  • 14
    Abrams GA, Jaffe CC, Hoffer PB, Binder HJ, Fallon MB. Diagnostic utility of contrast echocardiography and lung perfusion scan in patients with hepatopulmonary syndrome. Gastroenterology 1995; 109: 12831288.
  • 15
    Swanson KL, Wiesner RH, Krowka MJ. Natural history of hepatopulmonary syndrome: Impact of liver transplantation. Hepatology 2005; 41: 11221129.
  • 16
    Rodriquez-Roisin R, Krowka MJ, Herve P, Fallon MB. Highlights of the ERS Task Force on pulmonary–hepatic vascular disorders (PHD). J Hepatol 2005; 42: 924927.
  • 17
    Rodriguez-Roisin R, Krowka MJ, Herve P, Fallon MB. Pulmonary–hepatic vascular disorders (PHD). Eur Respir J 2004; 24: 861880.
  • 18
    Taille C, Cadranel J, Bellocq A et al. Liver transplantation for hepatopulmonary syndrome: A ten-year experience in Paris, France. Transplantation 2003; 75: 14821489; discussion 1446–1447.
  • 19
    Arguedas MR, Abrams GA, Krowka MJ, Fallon MB. Prospective evaluation of outcomes and predictors of mortality in patients with hepatopulmonary syndrome undergoing liver transplantation. Hepatology 2003; 37: 192197.
  • 20
    Cardus J, Burgos F, Diaz O et al. Increase in pulmonary ventilation–perfusion inequality with age in healthy individuals. Am J Respir Crit Care Med 1997; 156: 648653.
  • 21
    Martinez GP, Barbera JA, Visa J et al. Hepatopulmonary syndrome in candidates for liver transplantation. J Hepatol 2001; 34: 651657.
  • 22
    Groszmann RJ, Glickman M, Blei AT, Storer E, Conn HO. Wedged and free hepatic venous pressure measured with a balloon catheter. Gastroenterology 1979; 76: 253258.
  • 23
    American Thoracic Society. Single-breath carbon monoxide diffusing capacity (transfer factor). Recommendations for a standard technique—1995 update. Am J Respir Crit Care Med 1995; 152: 21852198.
  • 24
    McCulloch M, Gresser C, Moos S et al. Ultrasound contrast physics: A series on contrast echocardiography, article 3. J Am Soc Echocardiogr 2000; 13: 959967.
  • 25
    Krowka MJ, Cortese DA. Hepatopulmonary syndrome. Current concepts in diagnostic and therapeutic considerations. Chest 1994; 105: 15281537.
  • 26
    Schenk P, Fuhrmann V, Madl C et al. Hepatopulmonary syndrome: Prevalence and predictive value of various cut offs for arterial oxygenation and their clinical consequences. Gut 2002; 51: 853859.
  • 27
    Mohamed R, Freeman JW, Guest PJ, Davies MK, Neuberger JM. Pulmonary gas exchange abnormalities in liver transplant candidates. Liver Transpl 2002; 8: 802808.
  • 28
    Krowka MJ, Mandell MS, Ramsay MA et al. Hepatopulmonary syndrome and portopulmonary hypertension: A report of the multicenter liver transplant database. Liver Transpl 2004; 10: 174182.
  • 29
    Collisson EA, Nourmand H, Fraiman MH et al. Retrospective analysis of the results of liver transplantation for adults with severe hepatopulmonary syndrome. Liver Transpl 2002; 8: 925931.
  • 30
    Krowka MJ, Porayko MK, Plevak DJ et al. Hepatopulmonary syndrome with progressive hypoxemia as an indication for liver transplantation: Case reports and literature review. Mayo Clin Proc 1997; 72: 4453.