• 1
    Boehm U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-γ. Ann Rev Immunol 1997; 15: 749795.
  • 2
    Hidalgo LG, Halloran PF. Role of IFN-gamma in allograft rejection. Crit Rev Immunol 2002; 22: 317349.
  • 3
    Wadgymar A, Urmson J, Baumal R, Halloran PF. Changes in Ia expression in mouse kidney during acute graft-vs-host disease. J Immunol 1984; 132: 18261832.
  • 4
    Bishop GA, Hall BM, Phillips J et al. Expression of HLA-DR antigens on renal tubular cells during rejection. Transplant Proc 1985; 17: 6465.
  • 5
    Sinclair GD, Wadgymar A, Halloran PF, Delovitch TL. Graft-vs-host reactions induce H-2 class II gene transcription in host kidney cells. Immunogenetics 1984; 20: 503511.
  • 6
    Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003; 3: 2335.
  • 7
    Pilmore HL, Painter DM, Bishop GA, McCaughan GW, Eris JM. Early up-regulation of macrophages and myofibroblasts: A new marker for development of chronic renal allograft rejection. Transplant 2000; 69: 26582662.
  • 8
    Halloran PF, Jephthah-Ochola J, Urmson J, Farkas S. Systemic immunologic stimuli increase class I and II antigen expression in mouse kidney. J Immunol 1985; 135: 10531060.
  • 9
    Fairchild RL. The Yin and Yang of IFN-gamma in allograft rejection. Am J Transplant 2003; 3: 913914.
  • 10
    Halloran PF, Miller LW, Urmson J et al. IFN-gamma alters the pathology of graft rejection: Protection from early necrosis. J Immunol 2001; 166: 70727081.
  • 11
    Halloran PF, Afrouzian M, Ramassar V et al. Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis. Am J Pathol 2001; 158: 215226.
  • 12
    Sarwal M, Chua MS, Kambham N et al. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003; 349: 125138.
  • 13
    Akalin E, Hendrix RC, Polavarapu RG et al. Gene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology. Transplant 2001; 72: 948953.
  • 14
    Flechner SM, Kurian SM, Head SR et al. Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant 2004; 4: 14751489.
  • 15
    Einecke G, Melk A, Ramassar V et al. Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated kidney graft rejection. Am J Transplant 2005; 5: 18271836.
  • 16
    Saiura A, Mataki C, Murakami T et al. A comparison of gene expression in murine cardiac allografts and isografts by means DNA microarray analysis. Transplant 2001; 72: 320329.
  • 17
    Saiura A, Kohro T, Yamamoto T et al. Detection of an up-regulation of a group of chemokine genes in murine cardiac allograft in the absence of interferon-gamma by means of DNA microarray. Transplant 2002; 73: 14801486.
  • 18
    Jabs WJ, Sedlmeyer A, Ramassar V et al. Heterogeneity in the evolution and mechanisms of the lesions of kidney allograft rejection in mice. Am J Transplant 2003; 3: 15011509.
  • 19
    Christopher K, Mueller TF, Liang Y, Finn PW, Perkins DL. Modulation of gene expression by alloimmune networks following murine heart transplantation. Mol Genet Genomics 2004; 271: 687696.
  • 20
    Gentleman R, Carey VJ, Huber W, Irizarry R, Dudoit S. Bioinformatics and Computational Biology Solutions Using R and Bioconductor, XII Ed. 2005. Springer, New York , London .
  • 21
    Smyth G. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3: Article 3.
  • 22
    Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 1998; 95: 1486314868.
  • 23
    Liu YC, Pan J, Zhang C et al. A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. Proc Natl Acad Sci U S A 1999; 96: 43134318.
  • 24
    Hipp MS, Kalveram B, Raasi S, Groettrup M, Schmidtke G. FAT10, a ubiquitin-independent signal for proteasomal degradation. Mol Cell Biol 2005; 25: 34833491.
  • 25
    Raasi S, Schmidtke G, Groettrup M. The ubiquitin-like protein FAT10 forms covalent conjugates and induces apoptosis. J Biol Chem 2001; 276: 3533435343.
  • 26
    Goes N, Urmson J, Vincent D, Halloran PF. Acute renal injury in the interferon-gamma gene knockout mouse: Effect on cytokine gene expression. Transplant 1995; 60: 15601564.
  • 27
    Shoskes DA, Halloran PF. Ischemic injury induces altered MHC gene expression in kidney by an interferon-gamma-dependent pathway. Transplant Proc 1991; 23: 599601.
  • 28
    Takeuchi O, Sims TN, Takei Y, Ramassar V, Famulski KS, Halloran PF. Differential usage of class II transactivator promoters PI and PIV during inflammation and injury in kidney. J Am Soc Nephrol 2003; 14: 28232832.
  • 29
    Shoskes D, Parfrey NA, Halloran PF. Increased major histocompatibility complex antigen expression in unilateral ischemic acute tubular necrosis in the mouse. Transplant 1990; 49: 201207.
  • 30
    Kim SJ, Varghese TK, Zhang Z et al. Renal ischemia/reperfusion injury activates the enhancer domain of the human cytomegalovirus major immediate early promoter. Am J Transplant 2005; 5: 16061613.
  • 31
    Reddy P. Pathophysiology of acute graft-versus-host disease. Hematol Oncol 2003; 21: 149161.
  • 32
    Liu Y. Hepatocyte growth factor in kidney fibrosis: Therapeutic potential and mechanisms of action. Am J Physiol Renal Physiol 2004; 287: F716.
  • 33
    Verrecchia F, Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: Role in extracellular matrix gene expression and regulation. J Invest Dermatol 2002; 118: 211215.
  • 34
    Stegall MD, Park WD, Kim DY, Covarrubias M, Khair A, Kremers WK. Changes in intragraft gene expression secondary to ischemia reperfusion after cardiac transplantation. Transplant 2002; 74: 924930.
  • 35
    Yoshida T, Tang SS, Hsiao LL, Jensen RV, Ingelfinger JR, Gullans SR. Global analysis of gene expression in renal ischemia–reperfusion in the mouse. Biochem Biophys Res Commun 2002; 291: 787794.
  • 36
    Jiang D, Liang J, Hodge J et al. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J Clin Invest 2004; 114: 291299.
  • 37
    Martin-Fontecha A, Thomsen LL, Brett S et al. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol 2004; 5: 12601265.
  • 38
    El Sawy T, Miura M, Fairchild R. Early T cell response to allografts occurring prior to alloantigen priming up-regulates innate-mediated inflammation and graft necrosis. Am J Pathol 2004; 165: 147157.
  • 39
    Burne-Taney MJ, Yokota-Ikeda N, Rabb H. Effects of combined T- and B-cell deficiency on murine ischemia reperfusion injury. Am J Transplant 2005; 5: 11861193.
  • 40
    Sibinga NE, Feinberg MW, Yang H, Werner F, Jain MK. Macrophage-restricted and interferon gamma-inducible expression of the allograft inflammatory factor-1 gene requires Pu.1. J Biol Chem 2002; 277: 1620216210.
  • 41
    Valledor AF, Hsu LC, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A 2004; 101: 1781317818.
  • 42
    Ikezumi Y, Atkins RC, Nikolic-Paterson DJ. Interferon-gamma augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism. J Am Soc Nephrol 2003; 14: 888898.
  • 43
    Yang ZF, Ho DW, Chu AC, Wang YQ, Fan ST. Linking inflammation to acute rejection in small-for-size liver allografts: The potential role of early macrophage activation. Am J Transplant 2004; 4: 196209.
  • 44
    Romagnani P, Lazzeri E, Lasagni L et al. IP-10 and Mig production by glomerular cells in human proliferative glomerulonephritis and regulation by nitric oxide. J Am Soc Nephrol 2002; 13: 5364.
  • 45
    Widney DP, Xia YR, Lusis AJ, Smith JB. The murine chemokine CXCL11 (IFN-inducible T cell alpha chemoattractant) is an IFN-gamma- and lipopolysaccharide-inducible glucocorticoid-attenuated response gene expressed in lung and other tissues during endotoxemia. J Immunol 2000; 164: 63226331.
  • 46
    Mueller TF, Ma C, Lederer JA, Perkins DL. Differentiation of stress, metabolism, communication, and defense responses following transplantation. J Leukoc Biol 2003; 73: 379390.