• 1
    Michaels PJ, Espejo ML, Kobashigawa J et al. Humoral rejection in cardiac transplantation: Risk factors, hemodynamic consequences and relationship to transplant coronary artery disease. J Heart Lung Transplant 2003; 22: 5869.
  • 2
    Hammond EH, Yowell RL, Nunoda S et al. Vascular (humoral) rejection in heart transplantation: Pathologic observations and clinical implications. J Heart Transplant 1989; 8: 430443.
  • 3
    Reed EF, Demetris AJ, Hammond E et al. Acute antibody mediated rejection of cardiac transplants. J Heart Lung Transplant 2006; 25: 153159.
  • 4
    Stewart S, Winters GL, C. FM, Tazelaar HD. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 2005; 24: 17101720.
  • 5
    Rose AG, Cooper DK. A histopathologic grading system of hyperacute (humoral, antibody-mediated) cardiac xenograft and allograft rejection. J Heart Lung Transplant 1996; 15: 804817.
  • 6
    Reinsmoen NL, Nelson K, Zeevi A. Anti-HLA antibody analysis and crossmatching in heart and lung transplantation. Transpl Immunol 2004; 13: 6371.
  • 7
    Bian H, Reed EF. Alloantibody-mediated class I signal transduction in endothelial cells and smooth muscle cells: Enhancement by IFN-gamma and TNF-alpha. J Immunol 1999; 163: 10101018.
  • 8
    Bian H, Harris PE, Reed EF. Ligation of HLA class I molecules on smooth muscle cells with anti-HLA antibodies induces tyrosine phosphorylation, fibroblast growth factor receptor expression and cell proliferation. Int Immunol 1998; 10: 13151323.
  • 9
    Jin YP, Fishbein MC, Said JW et al. Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells. Hum Immunol 2004; 65: 291302.
  • 10
    Jin YP, Jindra PT, Gong KW, Lepin EJ, Reed EF. Anti-HLA class I antibodies activate endothelial cells and promote chronic rejection. Transplantation 2005; 79(3 Suppl): S19S21.
  • 11
    Narayanan K, Jaramillo A, Phelan DL, Mohanakumar T. Pre-exposure to sub-saturating concentrations of HLA class I antibodies confers resistance to endothelial cells against antibody complement-mediated lysis by regulating Bad through the phosphatidylinositol 3-kinase/Akt pathway. Eur J Immunol 2004; 34: 23032312.
  • 12
    Salama AD, Delikouras A, Pusey CD et al. Transplant accommodation in highly sensitized patients: A potential role for Bcl-xL and alloantibody. Am J Transplant 2001; 1: 260269.
  • 13
    Le Bas-Bernardet S, Coupel S, Chauveau A, Soulillou JP, Charreau B. Vascular endothelial cells evade apoptosis triggered by human leukocyte antigen-DR ligation mediated by allospecific antibodies. Transplantation 2004; 78: 17291739.
  • 14
    Jin YP, Singh RP, Du ZY, Rajasekaran AK, Rozengurt E, Reed EF. Ligation of HLA class I molecules on endothelial cells induces phosphorylation of Src, paxillin, and focal adhesion kinase in an actin-dependent manner. J Immunol 2002; 168: 54155423.
  • 15
    Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18: 19261945.
  • 16
    Billingham ME, Cary NR, Hammond ME et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant 1990; 9: 587593.
  • 17
    Choe G, Horvath S, Cloughesy TF et al. Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 2003; 63: 27422746.
  • 18
    Bae GU, Seo DW, Kwon HK et al. Hydrogen peroxide activates p70(S6k) signaling pathway. J Biol Chem 1999; 274: 3259632602.
  • 19
    Turner CE. Paxillin and focal adhesion signalling. Nat Cell Biol 2000; 2: E231E236.
  • 20
    Thomas G. The S6 kinase signaling pathway in the control of development and growth. Biol Res 2002; 35: 305313.
  • 21
    Beitz JG, Kim IS, Calabresi P, Frackelton AR, Jr. Human microvascular endothelial cells express receptors for platelet-derived growth factor. Proc Natl Acad Sci U S A 1991; 88: 20212025.
  • 22
    Kanda S, Hodgkin MN, Woodfield RJ, Wakelam MJ, Thomas G, Claesson-Welsh L. Phosphatidylinositol 3′-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells. J Biol Chem 1997; 272: 2334723353.
  • 23
    Vinals F, Chambard JC, Pouyssegur J. p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation. J Biol Chem 1999; 274: 2677626782.
  • 24
    Hiraoka E, Kawashima S, Takahashi T, Rikitake Y, Hirase T, Yokoyama M. PI 3-kinase-Akt-p70 S6 kinase in hypertrophic responses to leukemia inhibitory factor in cardiac myocytes. Kobe J Med Sci 2003; 49: 2537.
  • 25
    Holzknecht ZE, Kuypers KL, Plummer TB et al. Apoptosis and cellular activation in the pathogenesis of acute vascular rejection. Circ Res 2002; 91: 11351141.
  • 26
    Flotow H, Thomas G. Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver. J Biol Chem 1992; 267: 30743078.
  • 27
    Hendrickx J, Doggen K, Weinberg EO, Van Tongelen P, Fransen P, De Keulenaer GW. Molecular diversity of cardiac endothelial cells in vitro and in vivo. Physiol Genomics 2004; 19: 198206.
  • 28
    Moldobaeva A, Wagner EM. Difference in proangiogenic potential of systemic and pulmonary endothelium: Role of CXCR2. Am J Physiol Lung Cell Mol Physiol 2005; 288: L1117L1123.
  • 29
    Lekmine F, Sassano A, Uddin S et al. Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res 2004; 295: 173182.
  • 30
    Cham CM, Gajewski TF. Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells. J Immunol 2005; 174: 46704677.
  • 31
    Lim HK, Choi YA, Park W et al. Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway. J Biol Chem 2003; 278: 4511745127.
  • 32
    Larsen TH, Hesketh JE, Rotevatn S, Greve G, Saetersdal T. Ribosome distribution in normal and infarcted rat hearts. Histochem J 1994; 26: 7989.
  • 33
    Rose ML. De novo production of antibodies after heart or lung transplantation should be regarded as an early warning system. J Heart Lung Transplant 2004; 23: 385395.
  • 34
    Lee PC, Terasaki PI, Takemoto SK et al. All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies. Transplantation 2002; 74: 11921194.
  • 35
    Zhang Q, Liang LW, Gjertson DW et al. Development of posttransplant antidonor HLA antibodies is associated with acute humoral rejection and early graft dysfunction. Transplantation 2005; 79: 591598.
  • 36
    Suciu-Foca N, Reed E, Marboe C et al. The role of anti-HLA antibodies in heart transplantation. Transplantation 1991; 51: 716724.