Successful Kidney Transplantation from Donor with Marfan's Syndrome
Article first published online: 23 MAY 2006
American Journal of Transplantation
Volume 6, Issue 8, pages 1972–1974, August 2006
How to Cite
Farese, S., Vogt, B., Frey, F. J. and Huynh-Do, U. (2006), Successful Kidney Transplantation from Donor with Marfan's Syndrome. American Journal of Transplantation, 6: 1972–1974. doi: 10.1111/j.1600-6143.2006.01389.x
- Issue published online: 23 MAY 2006
- Article first published online: 23 MAY 2006
- Received 16 March 2006, revised 28 March 2006 and accepted for publication 4 April 2006
- Kidney transplantation;
- Marfan's syndrome;
- organ donor
Marfan's syndrome is caused by mutations in the extracellular matrix protein fibrillin-1 with aortic aneurysm and dissection being its most life-threatening manifestations.
Kidney transplantation from donors with Marfan's syndrome has never been reported in the literature, possibly because of reticences due to the underlying connective tissue disease. Here, we report two patients with end-stage renal disease, transplanted with the kidneys from a donor with Marfan's syndrome who died of aortic dissection and cerebral hemorrhage. After delayed graft function in both recipients, renal function normalized with no renovascular complications and negative proteinuria for 6 years in one patient and 2 years in the other patient, who died from an ischemic cerebrovascular insult. Kidneys from organ donors with Marfan's syndrome might be suitable for transplantation.