• 1
    Shapiro AM, Lakey JR, Ryan EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230238.
  • 2
    Carlsson PO, Mattsson G. Oxygen tension and blood flow in relation to revascularization in transplanted adult and fetal rat pancreatic islets. Cell Transplant 2002; 11: 813820.
  • 3
    Nyqvist D, Kohler M, Wahlstedt H, Berggren PO. Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts. Diabetes 2005; 54: 22872293.
  • 4
    Biancone L, Ricordi C. Pancreatic islet transplantation: An update. Cell Transplant 2002; 11: 309311.
  • 5
    Lai Y, Schneider D, Kidszun A et al. Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets. Transplantation 2005; 79: 15301536.
  • 6
    Kirken RA, Wang YL. Molecular actions of sirolimus: Sirolimus and mTor. Transplant Proc 2003; 35(3 Suppl): 227S230S.
  • 7
    Hering BJ, Wijkstrom M. Sirolimus and islet transplants. Transplant Proc 2003; 35(3 Suppl): 187S190S.
  • 8
    Valente JF, Hricik D, Weigel K et al. Comparison of sirolimus vs. mycophenolate mofetil on surgical complications and wound healing in adult kidney transplantation. Am J Transplant 2003; 3: 11281134.
  • 9
    Lieberthal W, Fuhro R, Andry CC et al. Rapamycin impairs recovery from acute renal failure: Role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 2001; 281: F693F706.
  • 10
    Guba M, Von Breitenbuch P, Steinbauer M et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med 2002; 8: 128135.
  • 11
    Butzal M, Loges S, Schweizer M et al. Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro. Exp Cell Res 2004; 300: 6571.
  • 12
    Ricordi C, Lacy PE, Scharp DW. Automated islet isolation from human pancreas. Diabetes 1989; 38(Suppl 1): 140142.
  • 13
    Biancone L, Cantaluppi V, Romanazzi GM et al. Platelet-activating factor synthesis and response on pancreatic islet endothelial cells: Relevance for islet transplantation. Transplantation 2006; 81: 511518.
  • 14
    Biancone L, Cantaluppi V, Boccellino M et al. Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis. Am J Pathol 1999; 155: 17311739.
  • 15
    Dull T, Zufferey R, Kelly M et al. A third-generation lentivirus vector with a conditional packaging system. J Virol 1998; 72: 84638471.
  • 16
    Galimi F, Noll M, Kanazawa Y et al. Gene therapy of Fanconi anemia: Preclinical efficacy using lentiviral vectors. Blood 2002; 100: 27322736.
  • 17
    Montrucchio G, Lupia E, Battaglia E et al. Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis. J Exp Med 1994; 180: 377382.
  • 18
    Biancone L, Cantaluppi V, Duò D, Deregibus MC, Torre C, Camussi G. Role of l-selectin in the vascular homing of peripheral blood-derived endothelial progenitor cells. J Immunol 2004; 173: 52685274.
  • 19
    Jain RK, Schlenger K, Hockel M, Yuan F. Quantitative angiogenesis assays: Progress and problems. Nat Med 1997; 3: 12031208.
  • 20
    Bharat A, Benshoff N, Olack B, Ramachandran S, Desai NM, Mohanakumar T. Novel in vivo murine model to study islet potency: Engraftment and function. Transplantation 2005; 79: 16271630.
  • 21
    Olsson R, Carlsson PO. Better vascular engraftment and function in pancreatic islets transplanted without prior culture. Diabetologia 2005; 48: 469476.
  • 22
    Zhang N, Richter A, Suriawinata J et al. Elevated vascular endothelial growth factor production in islets improves islet graft vascularization. Diabetes 2004; 53: 963970.
  • 23
    Pileggi A, Ricordi C, Alessiani M, Inverardi L. Factors influencing Islet of Langerhans graft function and monitoring. Clin Chim Acta 2001; 310: 316.
  • 24
    Ryan EA, Paty BW, Senior PA et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54: 20602069.
  • 25
    Stallone G, Schena A, Infante B et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 2005; 352: 13171323.
  • 26
    Desai NM, Goss JA, Deng S et al. Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: Local immunosuppression or islet toxicity? Transplantation 2003; 76: 16231625.
  • 27
    Bell E, Cao X, Moibi JA et al. Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets. Diabetes 2003; 52: 27312739.
  • 28
    Woltman AM, De Fijter JW, Kamerling SW et al. Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages. Blood 2001; 98: 174180.
  • 29
    Shah SA, Potter MW, Ricciardi R, Perugini RA, Callery MP. FRAP-p70s6K signaling is required for pancreatic cancer cell proliferation. J Surg Res 2001; 97: 123130.
  • 30
    Vasir B, Jonas JC, Steil GM et al. Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets. Transplantation 2001; 71: 924935.
  • 31
    Linn T, Schneider K, Hammes HP et al. Angiogenic capacity of endothelial cells in islets of Langerhans. FASEB J 2003; 17: 881883.
  • 32
    Welsh M, Claesson-Welsh L, Hallberg A et al. Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis. Proc Natl Acad Sci U S A 1990; 87: 58075811.
  • 33
    Jin H, Varner J. Integrins: Roles in cancer development and as treatment targets. Br J Cancer 2004; 90: 561565.
  • 34
    Jimenez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med 2000; 6: 4148.
  • 35
    Johansson M, Mattsson G, Andersson A, Jansson L, Carlsson PO. Islet endothelial cells and pancreatic beta-cell proliferation: Studies in vitro and during pregnancy in adult rats. Endocrinology 2006; 147: 23152324.
  • 36
    Cheng K, Fraga D, Zhang C et al. Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets. Gene Ther 2004; 11: 11051116.
  • 37
    Garcia-Ocana A, Vasavada RC, Cebrian A et al. Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes 2001; 50: 27522762.
  • 38
    Kirk AD, Burkly LC, Batty DS et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999; 5: 686693.
  • 39
    Biancone L, Cantaluppi V, Camussi G. CD40-CD154 interaction in experimental and human disease (review). Int J Mol Med 1999; 3: 343353.
  • 40
    Koulmanda M, Smith RN, Qipo A, Weir G, Auchincloss H, Strom TB. Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: Nonimmunologic graft failure? Am J Transplant 2006; 6: 687696.
  • 41
    Park SY, Kim HW, Moon KC, Hong HK, Lee HS. mRNA expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in acute renal allograft rejection. Transplantation 2000; 69: 25542560.
  • 42
    Monti P, Mercalli A, Leone BE, Valerio DC, Allavena P, Piemonti L. Rapamycin impairs antigen uptake of human dendritic cells. Transplantation 2003; 75: 137145.