• 1
    Terasaki PI, Cecka JM, Gjertson DW, Takemoto S. High survival rates of kidney-transplants from spousal and living unrelated donors. N Engl J Med 1995; 333: 333336.
  • 2
    Gjertson DW, Cecka JM. Living unrelated donor kidney transplantation. Kidney Int 2000; 58: 491499.
  • 3
    Segel LD, VonHaag DW, Zhang J, Follette DM. Selective overexpression of inflammatory molecules in hearts from brain-dead rats. J Heart Lung Transplant 2002; 21: 804811.
  • 4
    Van Der Hoeven JA, Ploeg RJ, Postema F et al. Induction of organ dysfunction and up-regulation of inflammatory markers in the liver and kidneys of hypotensive brain dead rats: A model to study marginal organ donors. Transplantation 1999; 68: 18841890.
  • 5
    Van Der Hoeven JA, Ter Horst GJ, Molema G et al. Effects of brain death and hemodynamic status on function and immunologic activation of the potential donor liver in the rat. Ann Surg 2000; 232: 804813.
  • 6
    Takada M, Nadeau KC, Hancock WW et al. Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation 1998; 65: 15331542.
  • 7
    Pratschke J, Wilhelm MJ, Kusaka M et al. Accelerated rejection of renal allografts from brain-dead donors. Ann Surg 2000; 232: 263271.
  • 8
    Van Der Hoeven JAB, Lindell S, Van Schilfgaarde R et al. Donor brain death reduces survival after transplantation in rat livers preserved for 20 hr. Transplantation 2001; 72: 16321636.
  • 9
    Schuurs TA, Gerbens F, Van Der Hoeven JAB et al. Distinct transcriptional changes in donor kidneys upon brain death induction in rats: Insights in the processes of brain death. Am J Transplant 2004; 4: 19721981.
  • 10
    Kuecuek O, Mantouvalou L, Klemz R et al. Significant reduction of proinflammatory cytokines by treatment of the brain-dead donor. Transplant Proc 2005; 37: 387388.
  • 11
    Van Der Hoeven JAB, Molema G, Ter Horst GJ et al. Relationship between duration of brain death and hemodynamic (in)stability on progressive dysfunction and increased immunologic activation of donor kidneys. Kidney Int 2003; 64: 18741882.
  • 12
    Van Den Eijnden MM, Leuvenink HG, Ottens PJ et al. Effect of brain death and non-heart-beating kidney donation on renal function and injury: An assessment in the isolated perfused rat kidney. Exp Clin Transplant 2003; 1: 8595.
  • 13
    Pou S, Huang YI, Bhan A et al. A fluorophore-containing nitroxide as a probe to detect superoxide and hydroxyl radical generated by stimulated neutrophils. Anal Biochem 1993; 212: 8590.
  • 14
    Li BB, Gutierrez PL, Blough NV. Trace determination of hydroxyl radical in biological systems. Anal Chem 1997; 69: 42954302.
  • 15
    Harboe M. A method for determination of hemoglobin in plasma by near-ultraviolet spectrophotometry. Scan J Clin and Lab Invest 1959; 11: 6670.
  • 16
    Sakurai H, Chiba H, Miyoshi H, Sugita T, Toriumi W. I kappa B kinases phosphorylate NF-kappa B p65 subunit on serine 536 in the transactivation domain. J Biol Chem 1999; 274: 3035330356.
  • 17
    Yan SF, Fujita T, Lu JS et al. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med 2000; 6: 13551361.
  • 18
    Pratschke J, Wilhelm MJ, Kusaka M et al. Brain death and its influence on donor organ quality and outcome after transplantation. Transplantation 1999; 67: 343348.
  • 19
    Nijboer WN, Schuurs TA, Van Der Hoeven JAB, Ploeg RJ. Effect of brain death and donor treatment on organ inflammatory response and donor organ viability. Curr Opin Organ Transplant 2004; 9: 110115.
  • 20
    Baeuerle PA, Baltimore D. NF-kappa B: Ten years after. Cell 1996; 87: 1320.
  • 21
    Pahl HL. Activators and target genes of Rel/NF-kappa B transcription factors. Oncogene 1999; 18: 68536866.
  • 22
    Dewan MZ, Terashima K, Taruishi M et al. Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gamma c(null) mice: Suppression by an inhibitor against NF-kappa B. J Virol 2003; 77: 52865294.
  • 23
    Mabuchi S, Ohmichi M, Nishio Y et al. Inhibition of inhibitor of nuclear factor-kappa B phosphorylation increase the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Clin Cancer Res 2004; 10: 76457654.
  • 24
    Yan SF, Fujita T, Lu JS et al. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med 2000; 6: 13551361.
  • 25
    Ledwith BJ, Manam S, Troilo P, Joslyn DJ, Galloway SM, Nichols WW. Activation of immediate-early gene-expression by peroxisome proliferators in-vitro. Mol Carcinog 1993; 8: 2027.
  • 26
    Cicatiello L, Sica V, Bresciani F, Weisz A. Identification of a specific pattern of immediate-early gene activation-induced by estrogen during mitogenic stimulation of rat uterine cells. Receptor 1993; 3: 1730.
  • 27
    Nijboer WN, Schuurs TA, Van Der Hoeven JA et al. Effect of brain death on gene expression and tissue activation in human donor kidneys. Transplantation 2004; 78: 978986.
  • 28
    Morimoto RI, Santoro MG. Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection. Nat Biotechnol 1998; 16: 833838.
  • 29
    Otterbein LE, Soares MP, Yamashita K, Bach FH. Heme oxygenase-1: Unleashing the protective properties of heme. Trends Immunol 2003; 24: 449455.
  • 30
    Bauer M, Bauer I. Heme oxygenase-1: Redox regulation and role in the hepatic response to oxidative stress. Antioxid Redox Signal 2002; 4: 749758.
  • 31
    Herijgers P, Leunens V, TjandraMaga TB, Mubagwa K, Flameng W. Changes in organ perfusion after brain death in the rat and its relation to circulating catecholamines. Transplantation 1996; 62: 330335.
  • 32
    Avlonitis VS, Wigfield CH, Kirby JA, Dark JH. The hemodynamic mechanisms of lung injury and systemic inflammatory response following brain death in the transplant donor. Am J Transplant 2005; 5: 684693.
  • 33
    Kosieradzki M, Kuczynska J, Piwowarska J et al. Prognostic significance of free radicals: Mediated injury occurring in the kidney donor. Transplantation 2003; 75: 12211227.
  • 34
    Lopau K, Mark J, Schramm L, Heidbreder E, Wanner C. Hormonal changes in brain death and immune activation in the donor. Transpl Int 2000; 13(Suppl 1): S282S285.
  • 35
    Stangl M, Zerkaulen T, Theodorakis J et al. Influence of brain death on cytokine release in organ donors and renal transplants. Transplant Proc 2001; 33: 12841285.
  • 36
    Shen XY, Hamilton TA, Dicorleto PE. Thrombin-induced expression of the Kc gene in cultured aortic endothelial-cells—involvement of proteolytic activity and protein kinase-C. Biochim Biophys Acta 1990; 1049: 145150.
  • 37
    Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes—expression in leukocytes and wound tissue. Mol Cell Biol 1990; 10: 55965599.
  • 38
    Fisher AJ, Donnelly SC, Hirani N et al. Enhanced pulmonary inflammation in organ donors following fatal nontraumatic brain injury. Lancet 1999; 353: 14121413.
  • 39
    Fisher AJ, Donnelly SC, Hirani N et al. Elevated levels of interleukin-8 in donor lungs is associated with early craft failure after lung transplantation. Am J Respir Crit Care Med 2001; 163: 259265.
  • 40
    Kossmann T, Stahel PF, Lenzlinger PM et al. Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood-brain barrier dysfunction and nerve growth factor production. J Cereb Blood Flow Metab 1997; 17: 280289.
  • 41
    Mussack T, Biberthaler P, Kanz KG et al. Serum S-100B and interleukin-8 as predictive markers for comparative neurologic outcome analysis of patients after cardiac arrest and severe traumatic brain injury. Crit Care Med 2002; 30: 26692674.
  • 42
    Shivalkar B, Vanloon J, Wieland W, Plets C, Tjandramagha T, Flameng W. Variable effects of explosive or gradual increase of intracranial-pressure on myocardial structure and donor heart function. J Mol Cell Cardiol 1992; 24: 230239.
  • 43
    Amado JA, Lopezespadas F, Vazquezbarquero A et al. Blood-levels of cytokines in brain-dead patients—relationship with circulating hormones and acute-phase reactants. Metabolism 1995; 44: 812816.