All authors contributed to the manuscript, including the draft of their section and review of the overall final submission.
Protocol Biopsies in Renal Transplantation: Insights into Patient Management and Pathogenesis
Version of Record online: 22 JAN 2007
American Journal of Transplantation
Volume 7, Issue 3, pages 512–517, March 2007
How to Cite
Mengel, M., Chapman, J. R., Cosio, F. G., Cavaillé-Coll, M. W., Haller, H., Halloran, P. F., Kirk, A. D., Mihatsch, M. J., Nankivell, B. J., Racusen, L. C., Roberts, I. S., Rush, D. N., Schwarz, A., Serón, D., Stegall, M. D. and Colvin, R. B. (2007), Protocol Biopsies in Renal Transplantation: Insights into Patient Management and Pathogenesis. American Journal of Transplantation, 7: 512–517. doi: 10.1111/j.1600-6143.2006.01677.x
- Issue online: 22 JAN 2007
- Version of Record online: 22 JAN 2007
- Received 12 September 2006, revised 23 October 2006 and accepted for publication 14 November 2006
A 1-day symposium on the application of protocol biopsies in renal transplantation was held in Boston, 21 July 2006. Representatives from centers with extensive experience in the use of protocol biopsies for routine patient care and research reported results on the pathological findings and their value in patient management. The consensus was that protocol biopsies, in experienced hands, are a safe and valuable means of detecting subclinical disease that can benefit from modification of therapy. Furthermore, molecular studies reveal evidence of activity or progression not readily appreciated by histological techniques. Wider application is expected in multicenter clinical trials to predict and validate outcomes. The principal barrier to wider use of protocol biopsies is knowledge of the benefits of intervention.