There are no conflicts of interest to report.
The Medical Evaluation of Living Kidney Donors: A Survey of US Transplant Centers
Article first published online: 31 AUG 2007
American Journal of Transplantation
Volume 7, Issue 10, pages 2333–2343, October 2007
How to Cite
Mandelbrot, D. A., Pavlakis, M., Danovitch, G. M., Johnson, S. R., Karp, S. J., Khwaja, K., Hanto, D. W. and Rodrigue, J. R. (2007), The Medical Evaluation of Living Kidney Donors: A Survey of US Transplant Centers. American Journal of Transplantation, 7: 2333–2343. doi: 10.1111/j.1600-6143.2007.01932.x
- Issue published online: 31 AUG 2007
- Article first published online: 31 AUG 2007
- Received 28 March 2007, revised 12 June 2007 and accepted for publication 27 June 2007
- Kidney donor;
- living donation;
- renal transplantation
The use of living donors for kidney transplantation in the United States is common, and long-term studies have demonstrated the safety of donation by young, healthy individuals. However, transplant programs have little data to guide them in deciding which donors are unacceptable, and which characteristics are associated with kidney disease or poor psychosocial outcomes after donation. To document current practices in evaluating potential donors, we surveyed all US kidney transplant programs. Compared to a survey 12 years ago, medical criteria for donation are more inclusive in several areas. All responding programs now accept living unrelated donors. Most programs no longer have an upper age limit to be eligible. Programs are now more likely to accept donors with treated hypertension, or a history of kidney stones, provided that certain additional criteria are met. In contrast, medical criteria for donation are more restrictive in other areas, such as younger donor age and low creatinine clearance. Overall, significant variability remains among transplant programs in the criteria used to evaluate donors. These findings highlight the need for more data on long-term outcomes in various types of donors with potential morbidities related to donation.