The study was presented in part at the American Transplant Congress 2007, May 5–9, San Francisco, California, USA.
Comparison of Quantiferon-TB Gold With Tuberculin Skin Test for Detecting Latent Tuberculosis Infection Prior to Liver Transplantation
Article first published online: 30 OCT 2007
American Journal of Transplantation
Volume 7, Issue 12, pages 2797–2801, December 2007
How to Cite
Manuel, O., Humar, A., Preiksaitis, J., Doucette, K., Shokoples, S., Peleg, A. Y., Cobos, I. and Kumar, D. (2007), Comparison of Quantiferon-TB Gold With Tuberculin Skin Test for Detecting Latent Tuberculosis Infection Prior to Liver Transplantation. American Journal of Transplantation, 7: 2797–2801. doi: 10.1111/j.1600-6143.2007.02011.x
- Issue published online: 30 OCT 2007
- Article first published online: 30 OCT 2007
- Received 02 August 2007, revised 30 August 2007 and accepted for publication 31 August 2007
- End-stage liver disease;
- interferon-γ release assay;
- Mycobacterium tuberculosis;
- organ transplantation
Screening for latent tuberculosis infection (LTBI) is recommended prior to organ transplantation. The Quantiferon-TB Gold assay (QFT-G) may be more accurate than the tuberculin skin test (TST) in the detection of LTBI. We prospectively compared the results of QFT-G to TST in patients with chronic liver disease awaiting transplantation. Patients were screened for LTBI with both the QFT-G test and a TST. Concordance between test results and predictors of a discordant result were determined. Of the 153 evaluable patients, 37 (24.2%) had a positive TST and 34 (22.2%) had a positive QFT-G. Overall agreement between tests was 85.1% (κ= 0.60, p < 0.0001). Discordant test results were seen in 12 TST positive/QFT-G negative patients and in 9 TST negative/QFT-G positive patients. Prior BCG vaccination was not associated with discordant test results. Twelve patients (7.8%), all with a negative TST, had an indeterminate result of the QFT-G and this was more likely in patients with a low lymphocyte count (p = 0.01) and a high MELD score (p = 0.001). In patients awaiting liver transplantation, both the TST and QFT-G were comparable for the diagnosis of LTBI with reasonable concordance between tests. Indeterminate QFT-G result was more likely in those with more advanced liver disease.