Outcome of Renal Transplantation in Eight Patients with Candida sp. Contamination of Preservation Fluid

Authors

  • M. Matignon,

    1. Nephrology Unit, Henri Mondor Hospital, AP-HP, Institut Francilien de Techerche en Néphrologie et Transplantation (IFRNT) and Paris XII University, Créteil, France
    Search for more papers by this author
  • F. Botterel,

    1. Mycology and Parasitology Unit, Henri Mondor Hospital, AP-HP, Créteil, France
    Search for more papers by this author
  • V. Audard,

    1. Nephrology Unit, Henri Mondor Hospital, AP-HP, Institut Francilien de Techerche en Néphrologie et Transplantation (IFRNT) and Paris XII University, Créteil, France
    Search for more papers by this author
  • B. Dunogue,

    1. Nephrology Unit, Henri Mondor Hospital, AP-HP, Institut Francilien de Techerche en Néphrologie et Transplantation (IFRNT) and Paris XII University, Créteil, France
    Search for more papers by this author
  • K. Dahan,

    1. Nephrology Unit, Henri Mondor Hospital, AP-HP, Institut Francilien de Techerche en Néphrologie et Transplantation (IFRNT) and Paris XII University, Créteil, France
    Search for more papers by this author
  • P. Lang,

    1. Nephrology Unit, Henri Mondor Hospital, AP-HP, Institut Francilien de Techerche en Néphrologie et Transplantation (IFRNT) and Paris XII University, Créteil, France
    Search for more papers by this author
  • S. Bretagne,

    1. Mycology and Parasitology Unit, Henri Mondor Hospital, AP-HP, Créteil, France
    Search for more papers by this author
  • P. Grimbert

    Corresponding author
    1. Nephrology Unit, Henri Mondor Hospital, AP-HP, Institut Francilien de Techerche en Néphrologie et Transplantation (IFRNT) and Paris XII University, Créteil, France
      * Corresponding author: Philippe Grimbert, philippe.grimbert@hmn.aphp.fr
    Search for more papers by this author

* Corresponding author: Philippe Grimbert, philippe.grimbert@hmn.aphp.fr

Abstract

The complications of kidney graft preservation fluid infected by Candida sp. may range in severity from trivial infections to life-threatening complications, including graft arteritis and anastomotic rupture. Mandatory nephrectomy has recently been proposed as a means of preventing arterial wall rupture in such cases. We describe the clinical features and outcome of renal transplantation from a cadaveric donor in eight recipients with preservation fluid testing positive for Candida sp. Six patients were treated with antifungal drugs. After 1–2 years of follow-up, including regular imaging, none of the patients had developed arterial aneurysm, and all had a functional allograft and were alive. The contamination of renal graft preservation fluid with Candida sp. may be uneventful and should not systematically lead to removal of the graft. Until other risk factors for vascular complications have been determined, early antifungal treatment and repeated radiological monitoring are advisable for the prevention and/or early detection of such complications.

Ancillary