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Correlation of Motility and Neuronal Integrity with a Focus on the Grade of Intestinal Allograft Rejection
Article first published online: 19 FEB 2008
DOI: 10.1111/j.1600-6143.2007.02115.x
2008 The Authors Journal compilation © 2008 The American Society of Transplantation and the American Society of Transplant Surgeons
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How to Cite
Watanabe, T., Hoshino, K., Tanabe, M., Kawachi, S., Wakabayashi, G., Shimazu, M., Morikawa, Y. and Kitajima, M. (2008), Correlation of Motility and Neuronal Integrity with a Focus on the Grade of Intestinal Allograft Rejection. American Journal of Transplantation, 8: 529–536. doi: 10.1111/j.1600-6143.2007.02115.x
Publication History
- Issue published online: 19 FEB 2008
- Article first published online: 19 FEB 2008
- Received 20 February 2007, revised 08 November 2007 and accepted for publication 09 November 2007
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Keywords:
- Motility;
- neuron;
- rejection;
- small bowel transplantation
Intestinal allograft dysmotility, such as absence of migrating motor complex and high prevalence of discrete clustered contraction or non-propagating contraction, could be a useful marker of progression of acute rejection and help guide treatment decisions.
Intestinal graft motility after small bowel transplantation (SBT) is poorly characterized. The aim of this study was to compare motor patterns with myenteric neuronal cell population as a parameter of graft viability at various degrees of acute cellular rejection (ACR). Three grades of ACR were achieved in orthotopic allografts. Syngeneic transplants and allografts with immunosuppression served as controls. Motor activities were recorded using strain gauge force transducers and analyzed visually. Quantifications of myenteric neurons in whole mounts of intestinal grafts were used to evaluate neuronal population. A typical migrating motor complex (MMC) was found in syngeneic and allogenic transplants with immunosuppression. A high prevalence of discrete clustered contractions (DCC) and nonpropagating contractions (NPC) without MMC was seen in moderately and severely rejected allografts. Neuronal cell loss in the allografts, which could be one of the causes of motor dysfunction, was noted in moderate rejection (19.3%) and progressed until severe rejection (60.1%). Monitoring motility patterns in SBT could be an effective tool for assessing intestinal rejection. Allograft dysmotility, such as absence of MMC and high prevalence of DCC or NPC, could be useful markers of progression of acute rejection and help guide treatment decisions.