These authors contributed equally to this work. The authors declare no competing financial interests.
THIS ARTICLE HAS BEEN RETRACTED Essential Role of Sphingosine-1-Phosphate Receptor 1-Bearing CD8+CD44+CCR7+ T Cells in Acute Skin Allograft Rejection
Article first published online: 28 JUN 2008
© 2008 The Authors Journal compilation © 2008 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 8, Issue 7, pages 1401–1412, July 2008
How to Cite
Yuling, H., Ruijing, X., Xiang, J., Luokun, X., Wenjun, Y., Feng, C., Baojun, H., Hui, Y., Guang, Y., Chunlei, Y., Jixin, Z., Lang, C., Li, Q., Chang, A., Zhuan, B., Youxin, J., Feili, G. and Jinquan, T. (2008), THIS ARTICLE HAS BEEN RETRACTED Essential Role of Sphingosine-1-Phosphate Receptor 1-Bearing CD8+CD44+CCR7+ T Cells in Acute Skin Allograft Rejection. American Journal of Transplantation, 8: 1401–1412. doi: 10.1111/j.1600-6143.2008.02275.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Received 01 December 2007, revised 29 March 2008 and accepted for publication 31 March 2008
Vol. 11, Issue 6, 1343, Article first published online: 6 JUN 2011
- Acute allograft rejection;
- chemokine receptor;
- memory T cells;
A subset of naturally formed sphingosine-1-phosphate receptor 1 (S1P1)-bearing CD8+CD44+CCR7+ memory T cells has been identified in transplant recipient BALB/c (H-2d) mice. The frequency of this subset of memory T cells is significantly increased in the spleen, lymph nodes and skin grafts in the recipient BALB/c mice during acute skin allograft rejections. The immune-reconstitution with CD8+CD44+CCR7+S1P1+ memory T cells facilitates acute skin allograft rejection in SCID mice. Being Th1-polarized and cytotoxic, CD8+CD44+CCR7+S1P1+ memory T cells proliferate and differentiate immediately into effectors upon encountering allo-antigens. A siRNA against S1P1 inhibits CD8+CD44+CCR7+S1P1+ memory T cell-mediated acute skin allograft rejection in SCID mice by means of knocking-down S1P1-expression. CCL21 mutant (CCL21-ΔCT) has been used to compete with wild-type CCL21 in the course of binding to CCR7. Combined administration of siRNA S1P1 and CCL21-ΔCT significantly prolongs the survival of skin allograft in the recipient BALB/c mice by means of inhibiting accumulation of CD8+CD44+CCR7+S1P1+ memory T cells in the spleen and the skin grafts. Our data provide direct evidence that S1P1 and CCR7 are involved in the proliferation and trafficking of CD8+CD44+CCR7+S1P1+ memory T cells. S1P1 may serve as a functional marker for CD8+CD44+CCR7+ memory T cells. Targeting CD8+CD44+CCR7+S1P1+ T cells may be a useful strategy to prolong the survival of allograft transplant.