THIS ARTICLE HAS BEEN RETRACTED Essential Role of Sphingosine-1-Phosphate Receptor 1-Bearing CD8+CD44+CCR7+ T Cells in Acute Skin Allograft Rejection

Authors

  • H. Yuling,

    1. Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine, Wuhan, China
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    • These authors contributed equally to this work. The authors declare no competing financial interests.

  • X. Ruijing,

    1. Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine, Wuhan, China
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    • These authors contributed equally to this work. The authors declare no competing financial interests.

  • J. Xiang,

    1. Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine, Wuhan, China
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    • These authors contributed equally to this work. The authors declare no competing financial interests.

  • X. Luokun,

    1. Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine, Wuhan, China
    2. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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    • These authors contributed equally to this work. The authors declare no competing financial interests.

  • Y. Wenjun,

    1. Department of Orthodontics, Wuhan University School of Stomatology, Wuhan, China
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    • These authors contributed equally to this work. The authors declare no competing financial interests.

  • C. Feng,

    1. Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine, Wuhan, China
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    • These authors contributed equally to this work. The authors declare no competing financial interests.

  • H. Baojun,

    1. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    2. Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China
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  • Y. Hui,

    1. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Y. Guang,

    1. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Y. Chunlei,

    1. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Z. Jixin,

    1. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • C. Lang,

    1. Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine, Wuhan, China
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  • Q. Li,

    1. Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine, Wuhan, China
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  • A. Chang,

    1. Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine, Wuhan, China
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  • B. Zhuan,

    1. Department of Orthodontics, Wuhan University School of Stomatology, Wuhan, China
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  • J. Youxin,

    1. The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, China
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  • G. Feili,

    Corresponding author
    1. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • T. Jinquan

    Corresponding author
    1. Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine, Wuhan, China
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Errata

This article is corrected by:

  1. Errata: Retraction Volume 11, Issue 6, 1343, Article first published online: 6 June 2011

Corresponding authors: Gong Feili, flgong@tjmu.edu.cn ; Tan Jinquan,jinquan_tan@whu.edu.cn

Abstract

A subset of naturally formed sphingosine-1-phosphate receptor 1 (S1P1)-bearing CD8+CD44+CCR7+ memory T cells has been identified in transplant recipient BALB/c (H-2d) mice. The frequency of this subset of memory T cells is significantly increased in the spleen, lymph nodes and skin grafts in the recipient BALB/c mice during acute skin allograft rejections. The immune-reconstitution with CD8+CD44+CCR7+S1P1+ memory T cells facilitates acute skin allograft rejection in SCID mice. Being Th1-polarized and cytotoxic, CD8+CD44+CCR7+S1P1+ memory T cells proliferate and differentiate immediately into effectors upon encountering allo-antigens. A siRNA against S1P1 inhibits CD8+CD44+CCR7+S1P1+ memory T cell-mediated acute skin allograft rejection in SCID mice by means of knocking-down S1P1-expression. CCL21 mutant (CCL21-ΔCT) has been used to compete with wild-type CCL21 in the course of binding to CCR7. Combined administration of siRNA S1P1 and CCL21-ΔCT significantly prolongs the survival of skin allograft in the recipient BALB/c mice by means of inhibiting accumulation of CD8+CD44+CCR7+S1P1+ memory T cells in the spleen and the skin grafts. Our data provide direct evidence that S1P1 and CCR7 are involved in the proliferation and trafficking of CD8+CD44+CCR7+S1P1+ memory T cells. S1P1 may serve as a functional marker for CD8+CD44+CCR7+ memory T cells. Targeting CD8+CD44+CCR7+S1P1+ T cells may be a useful strategy to prolong the survival of allograft transplant.

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