• 1
    Fishman JA, Emery V, Freeman R et al. Cytomegalovirus in transplantation–challenging the status quo. Clin Transplant 2007; 21: 149158.
  • 2
    Walter EA, Greenberg PD, Gilbert MJ et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 1995; 333: 10381044.
  • 3
    Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME, Greenberg PD. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 1992; 257: 238241.
  • 4
    Einsele H, Roosnek E, Rufer N, et al. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood 2002; 99: 39163922.
  • 5
    Reusser P, Cathomas G, Attenhofer R, Tamm M, Thiel G. Cytomegalovirus (CMV)-specific T cell immunity after renal transplantation mediates protection from CMV disease by limiting the systemic virus load. J Infect Dis 1999; 180: 247253.
  • 6
    Radha R, Jordan S, Puliyanda D et al. Cellular immune responses to cytomegalovirus in renal transplant recipients. Am J Transplant 2005; 5: 110117.
  • 7
    Gerna G, Lilleri D, Fornara C et al. Monitoring of human cytomegalovirus-specific CD4 and CD8 T-cell immunity in patients receiving solid organ transplantation. Am J Transplant 2006; 6: 23562364.
  • 8
    Sester M, Sester U, Gartner B et al. Levels of virus-specific CD4 T cells correlate with cytomegalovirus control and predict virus-induced disease after renal transplantation. Transplantation 2001; 71: 12871294.
  • 9
    Hassan-Walker AF, Vargas Cuero AL, Mattes FM et al. CD8+ cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: Correlation with time from transplant to receipt of tacrolimus. J Infect Dis 2001; 183: 835843.
  • 10
    Bunde T, Kirchner A, Hoffmeister B et al. Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells. J Exp Med 2005; 201: 10311036.
  • 11
    Gamadia LE, Remmerswaal EB, Weel JF, Bemelman F, Van Lier RA, Ten Berge IJ. Primary immune responses to human CMV: A critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease. Blood 2003; 101: 26862692.
  • 12
    Docke WD, Prosch S, Fietze E et al. Cytomegalovirus reactivation and tumour necrosis factor. Lancet 1994; 343: 268269.
  • 13
    Fietze E, Prosch S, Reinke P et al. Cytomegalovirus infection in transplant recipients. The role of tumor necrosis factor. Transplantation 1994; 58: 675680.
  • 14
    Nordoy I, Muller F, Nordal KP et al. The role of the tumor necrosis factor system and interleukin-10 during cytomegalovirus infection in renal transplant recipients. J Infect Dis 2000; 181: 5157.
  • 15
    Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB. Interleukin-10 and related cytokines and receptors. Annu Rev Immunol 2004; 22: 929979.
  • 16
    Essa S, Raghupathy R, Pacsa AS, El-Shazly A, Said T, Azizieh F. Th1-type cytokines production is decreased in kidney transplant recipients with active cytomegalovirus infection. J Med Virol 2000; 60: 223229.
  • 17
    Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002; 34: 10941097.
  • 18
    Harari A, Vallelian F, Meylan PR, Pantaleo G. Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J Immunol 2005; 174:10371045.
  • 19
    Boaz MJ, Waters A, Murad S, Easterbrook PJ, Vyakarnam A. Presence of HIV-1 Gag-specific IFN-gamma+IL-2 +and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection. J Immunol 2002; 169: 63766385.
  • 20
    Darrah PA, Patel DT, De Luca PM et al. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med 2007; 13: 843850.
  • 21
    Emu B, Sinclair E, Favre D et al. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol 2005; 79: 1416914178.
  • 22
    Younes SA, Yassine-Diab B, Dumont AR et al. HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. J Exp Med 2003; 198: 19091922.
  • 23
    Millington KA, Innes JA, Hackforth S et al. Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load. J Immunol 2007; 178: 52175226.
  • 24
    Picker LJ, Singh MK, Zdraveski Z et al. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 1995; 86: 14081419.
  • 25
    Mattes FM, Hainsworth EG, Hassan-Walker AF et al. Kinetics of cytomegalovirus load decrease in solid-organ transplant recipients after preemptive therapy with valganciclovir. J Infect Dis 2005; 191: 8992.
  • 26
    Fishman JA, Rubin RH. Infection in organ-transplant recipients. N Engl J Med 1998; 338: 17411751.
  • 27
    Harari A, Dutoit V, Bart PA, Du Pasquier RA and Pantaleo G. Functional signatures of protective antiviral T-cell immunity in human virus infections. Immunol Rev 2006; 211: 236254.
  • 28
    Lacey SF, La Rosa C, Zhou W et al. Functional comparison of T cells recognizing cytomegalovirus pp65 and intermediate-early antigen polypeptides in hematopoietic stem-cell transplant and solid organ transplant recipients. J Infect Dis 2006; 194: 14101421.
  • 29
    Lacey SF, Martinez J, Gallez-Hawkins G et al. Simultaneous reconstitution of multiple cytomegalovirus-specific CD8 +cell populations with divergent functionality in hematopoietic stem-cell transplant recipients. J Infect Dis 2005; 191: 977984.
  • 30
    Lilleri D, Zelini P, Fornara C, Comolli G, Gerna G. Inconsistent responses of cytomegalovirus-specific T cells to pp65 and IE-1 versus infected dendritic cells in organ transplant recipients. Am J Transplant 2007; 7: 19972005.
  • 31
    La Rosa C, Limaye AP, Krishnan A, Longmate J, Diamond DJ. Longitudinal assessment of cytomegalovirus (CMV)-specific immune responses in liver transplant recipients at high risk for late CMV disease. J Infect Dis 2007; 195: 633644.
  • 32
    Sester U, Gartner BC, Wilkens H et al. Differences in CMV-specific T-cell levels and long-term susceptibility to CMV infection after kidney, heart and lung transplantation. Am J Transplant 2005; 5: 14831489.
  • 33
    Harari A, Petitpierre S, Vallelian F, Pantaleo G. Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: Changes after antiretroviral therapy. Blood 2004; 103: 966972.
  • 34
    Zedtwitz-Liebenstein K, Jaksch P, Wulkersdorfer B et al. Usefulness of interleukin-10 detection in lung transplant patients with human cytomegalovirus infection with respect to virus persistence. Transplantation 2007; 84: 268271.
  • 35
    Reddy V, Meier-Kriesche HU, Greene S, Schold JD, Wingard JR. Increased levels of tumor necrosis factor alpha are associated with an increased risk of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2005; 11: 698705.
  • 36
    Emery VC, Sabin CA, Cope AV, Gor D, Hassan-Walker AF, Griffiths PD. Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation. Lancet 2000; 355: 20322036.
  • 37
    Regoes RR, Bowen EF, Cope AV et al. Modelling cytomegalovirus replication patterns in the human host: Factors important for pathogenesis. Proc Biol Sci 2006; 273: 19611967.