This is publication number 11 of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study.
Incidence and Severity of Acute Cellular Rejection in Recipients Undergoing Adult Living Donor or Deceased Donor Liver Transplantation‡
Article first published online: 15 DEC 2008
© 2009 The Authors Journal compilation © 2009 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 9, Issue 2, pages 301–308, February 2009
How to Cite
Shaked, A., Ghobrial, R. M., Merion, R. M., Shearon, T. H., Emond, J. C., Fair, J. H., Fisher, R. A., Kulik, L. M., Pruett, T. L., Terrault, N. A. and the A2ALL Study Group (2009), Incidence and Severity of Acute Cellular Rejection in Recipients Undergoing Adult Living Donor or Deceased Donor Liver Transplantation. American Journal of Transplantation, 9: 301–308. doi: 10.1111/j.1600-6143.2008.02487.x
- Issue published online: 27 JAN 2009
- Article first published online: 15 DEC 2008
- Received 20 February 2008, revised 16 September 2008, and accepted for publication 02 October 2008.
- Acute rejection;
- cold ischemia injury;
- liver regeneration
Living donor liver transplantation (LDLT) may have better immunological outcomes compared to deceased donor liver transplantation (DDLT). The aim of this study was to analyze the incidence of acute cellular rejection (ACR) after LDLT and DDLT. Data from the adult-to-adult living donor liver transplantation (A2ALL) retrospective cohort study on 593 liver transplants done between May 1998 and March 2004 were studied (380 LDLT; 213 DDLT). Median LDLT and DDLT follow-up was 778 and 713 days, respectively. Rates of clinically treated and biopsy-proven ACR were compared. There were 174 (46%) LDLT and 80 (38%) DDLT recipients with ≥1 clinically treated episodes of ACR, whereas 103 (27%) LDLT and 58 (27%) DDLT recipients had ≥1 biopsy-proven ACR episode. A higher proportion of LDLT recipients had clinically treated ACR (p = 0.052), but this difference was largely attributable to one center. There were similar proportions of biopsy-proven rejection (p = 0.97) and graft loss due to rejection (p = 0.16). Longer cold ischemia time was associated with a higher rate of ACR in both groups despite much shorter median cold ischemia time in LDLT. These data do not show an immunological advantage for LDLT, and therefore do not support the application of unique posttransplant immunosuppression protocols for LDLT recipients.