Donor Intervention and Organ Preservation: Where Is the Science and What Are the Obstacles?
Version of Record online: 20 APR 2010
©2010 The Authors Journal compilation©2010 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 10, Issue 5, pages 1155–1162, May 2010
How to Cite
Feng, S. (2010), Donor Intervention and Organ Preservation: Where Is the Science and What Are the Obstacles?. American Journal of Transplantation, 10: 1155–1162. doi: 10.1111/j.1600-6143.2010.03100.x
- Issue online: 20 APR 2010
- Version of Record online: 20 APR 2010
- Received 23 November 2009, revised 19 February 2010 and accepted for publication 19 February 2010
- graft function;
The organ shortage is widely acknowledged as the most critical factor hindering the full realization of success for solid organ transplantation. Innovation in the areas of donor management and organ preservation offers the most realistic hope to improve both the quality and size of the current organ supply. Although the basic science dissecting the complex processes of brain death and ischemia/reperfusion injury is replete with exciting discoveries, the clinical science investigating donor management and organ preservation is sparse in contrast. This review will survey the current landscape of trials to mitigate organ injury through interventions administered to donors in vivo or organs ex vivo. Consideration will then be given to the scientific, logistical and ethical obstacles that impede the transformation of laboratory breakthroughs into innovative treatments that simultaneously improve organ quality and supply.