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Lung Cancer after Heart Transplantation: Results from a Large Multicenter Registry

  1. M. G. Crespo-Leiro1,*,
  2. A. Villa-Arranz2,
  3. N. Manito-Lorite3,
  4. M. J. Paniagua-Martin1,
  5. G. Rábago4,
  6. L. Almenar-Bonet5,
  7. L. Alonso-Pulpón6,
  8. S. Mirabet-Pérez7,
  9. B. Diaz-Molina8,
  10. F. González-Vilchez9,
  11. J. M. Arizón de Prado10,
  12. N. Romero-Rodriguez11,
  13. J. Delgado-Jimenez12,
  14. E. Roig13,
  15. T. Blasco-Peiró14,
  16. D. Pascual-Figal15,
  17. L. De la Fuente Galán16,
  18. J. Muñiz17

Article first published online: 26 APR 2011

DOI: 10.1111/j.1600-6143.2011.03515.x

Issue

American Journal of Transplantation

American Journal of Transplantation

Volume 11, Issue 5, pages 1035–1040, May 2011

Additional Information

How to Cite

Crespo-Leiro, M. G., Villa-Arranz, A., Manito-Lorite, N., Paniagua-Martin, M. J., Rábago, G., Almenar-Bonet, L., Alonso-Pulpón, L., Mirabet-Pérez, S., Diaz-Molina, B., González-Vilchez, F., Arizón de Prado, J. M., Romero-Rodriguez, N., Delgado-Jimenez, J., Roig, E., Blasco-Peiró, T., Pascual-Figal, D., De la Fuente Galán, L. and Muñiz, J. (2011), Lung Cancer after Heart Transplantation: Results from a Large Multicenter Registry. American Journal of Transplantation, 11: 1035–1040. doi: 10.1111/j.1600-6143.2011.03515.x

Author Information

  1. 1

    Hospital Universitario A Coruña, La Coruña

  2. 2

    Hospital General Universitario Gregorio Marañón, Madrid

  3. 3

    Hospital Universitario de Bellvitge, Barcelona

  4. 4

    Clínica Universitaria de Navarra, Pamplona

  5. 5

    Hospital Universitario La Fe, Valencia

  6. 6

    Clínica Puerta de Hierro, Madrid

  7. 7

    Hospital de la Santa Creu I Sant Pau, Barcelona

  8. 8

    Hospital Universitario Central de Asturias, Oviedo

  9. 9

    Hospital Universitario Marqués de Valdecilla, Santander

  10. 10

    Hospital Universitario Reina Sofía, Córdoba

  11. 11

    Hospital Universitario Virgen del Rocío, Sevilla

  12. 12

    Hospital Universitario 12 de Octubre, Madrid

  13. 13

    Hospital Clinic I Provincial, Barcelona

  14. 14

    Hospital Miguel Servet, Zaragoza

  15. 15

    Hospital Universitario Virgen de la Arrixaca, Murcia

  16. 16

    Hospital Clínico de Valladolid, Valladolid

  17. 17

    Instituto Ciencias de la Salud, Universidad de A Coruña

*Corresponding author: Maria G. Crespo-Leiro, marisa.crespo.leiro@sergas.es

Publication History

  1. Issue published online: 26 APR 2011
  2. Article first published online: 26 APR 2011
  3. Received 07 December 2011, revised 17 February 2011 and accepted for publication 21 February 2011

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Keywords:

  • Heart transplantation;
  • lung cancer

In this study we analyzed Spanish Post-Heart-Transplant Tumour Registry data for adult heart transplantation (HT) patients since 1984. Median post-HT follow-up of 4357 patients was 6.7 years. Lung cancer (mainly squamous cell or adenocarcinoma) was diagnosed in 102 (14.0% of patients developing cancers) a mean 6.4 years post-HT. Incidence increased with age at HT from 149 per 100 000 person-years among under-45s to 542 among over-64s; was 4.6 times greater among men than women; and was four times greater among pre-HT smokers (2169 patients) than nonsmokers (2188). The incidence rates in age-at-diagnosis groups with more than one case were significantly greater than GLOBOCAN 2002 estimates for the general Spanish population, and comparison with published data on smoking and lung cancer in the general population suggests that this increase was not due to a greater prevalence of smokers or former smokers among HT patients. Curative surgery, performed in 21 of the 28 operable cases, increased Kaplan–Meier 2−year survival to 70% versus 16% among inoperable patients.

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