S.B and A.S-F share senior authorship.
Comparison of Transcriptional and Blood Cell-Phenotypic Markers Between Operationally Tolerant Liver and Kidney Recipients
Article first published online: 9 AUG 2011
© 2011 The Authors Journal compilation © 2011 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 11, Issue 9, pages 1916–1926, September 2011
How to Cite
Lozano, J. J., Pallier, A., Martinez-Llordella, M., Danger, R., López, M., Giral, M., Londoño, M. C., Rimola, A., Soulillou, J. P., Brouard, S. and Sánchez-Fueyo, A. (2011), Comparison of Transcriptional and Blood Cell-Phenotypic Markers Between Operationally Tolerant Liver and Kidney Recipients. American Journal of Transplantation, 11: 1916–1926. doi: 10.1111/j.1600-6143.2011.03638.x
- Issue published online: 29 AUG 2011
- Article first published online: 9 AUG 2011
- Received 27 December 2010, revised 03 May 2011 and accepted for publication 10 May 2011
- Gene expression;
- kidney transplantation;
- liver transplantation;
- operational tolerance;
A proportion of transplant recipients can spontaneously accept their grafts in the absence of immunosuppression (operational tolerance). Previous studies identified blood transcriptional and cell-phenotypic markers characteristic of either liver or kidney tolerant recipients. However, the small number of patients analyzed and the use of different transcriptional platforms hampered data interpretation. In this study we directly compared samples from kidney and liver tolerant recipients in order to identify potential similarities in immune-related parameters. Liver and kidney tolerant recipients differed in blood expression and B-cell immunophenotypic patterns and no significant overlaps were detectable between them. Whereas some recipients coincided in specific NK-related transcripts, this observation was not reproducible in all cohorts analyzed. Our results reveal that certain immune features, but not others, are consistently present across all cohorts of operationally tolerant recipients. This provides a set of reproducible biomarkers that should be explored in future large-scale immunomonitoring trials.