S.B and A.S-F share senior authorship.
Comparison of Transcriptional and Blood Cell-Phenotypic Markers Between Operationally Tolerant Liver and Kidney Recipients
Version of Record online: 9 AUG 2011
© 2011 The Authors Journal compilation © 2011 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 11, Issue 9, pages 1916–1926, September 2011
How to Cite
Lozano, J. J., Pallier, A., Martinez-Llordella, M., Danger, R., López, M., Giral, M., Londoño, M. C., Rimola, A., Soulillou, J. P., Brouard, S. and Sánchez-Fueyo, A. (2011), Comparison of Transcriptional and Blood Cell-Phenotypic Markers Between Operationally Tolerant Liver and Kidney Recipients. American Journal of Transplantation, 11: 1916–1926. doi: 10.1111/j.1600-6143.2011.03638.x
- Issue online: 29 AUG 2011
- Version of Record online: 9 AUG 2011
- Received 27 December 2010, revised 03 May 2011 and accepted for publication 10 May 2011
Figure S1: In blood samples from tolerant kidney recipients the enrichment in B-cell-related markers is stable over time. No differences in the frequency of CD19+ blood cells (A) and in the expression of CD20 (B), CD19 (C) and Bank1 (D), were observed when two sequential blood samples (0.8–4 years apart) from four K-Tol recipients were analyzed and flow cytometry and qPCR, respectively.
Figure S2: Blood samples from tolerant kidney recipients are enriched in B-cell-related transcripts when compared with stable kidney recipients but not with healthy individuals. Heatmap display of the 35 genes overlapping between the three cohorts of tolerant kidney recipients analyzed (Newell et al. in the upper panel, Sagoo et al. in the middle panel and our own experiments in the lower panel). For the three cohorts of patients the expression of each gene in tolerant recipients, stable recipients and healthy individuals is shown. Rows represent genes and columns represent samples. The intensity of each color denotes the standardized ratio between each value and the average expression of each gene across all samples. Red-colored pixels correspond to an increased abundance of the transcript in the indicated sample, whereas green pixels indicate decrease transcript levels. The 35 B-cell-related transcripts tend to be overexpressed in both tolerant kidney recipients (TOL) and healthy individuals (HC) and under-expressed in stable immunosuppressed kidney recipients (STA).
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